Pharmacotherapy of cough-variant asthma

Antoniu, Sabina A; Mihăescu, T; Donner, Claudio F.

doi:10.1517/14656566.8.17.3021

Cited by 12 publications

(2 citation statements)

References 52 publications

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“…In China, CVA is the most common cause of clinical chronic cough (32.6%), and it is also the leading cause of chronic cough in children, which seriously affects people’s daily life 5 – 7 . The current combined treatment of western medicine can alleviate the seasonal onset of CVA patients to a certain extent, relieve airway spasm and control airway inflammatory reaction 8 . In adults with CVA, traditional Chinese medicine (TCM) herbal medicine results in improved cough frequency and severity scores compared with western medicine Montelukast 9 .…”

Section: Introductionmentioning

confidence: 99%

Xiaoqinglong decoction suppresses childhood cough variant asthma and inhibited the body inflammatory response by regulating IL-6/STAT3 signalling pathway

Ren,

Li,

Zhang

et al. 2023

Annals of Medicine &Amp; Surgery

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Xiaoqinglong decoction (XQLD) is widely used clinically in the treatment of childhood cough variant asthma (CVA). However, its potential mechanism is still unknown. In the present study, we investigate the biological network and signaling pathway of XQLD in treatment of childhood CVA using network pharmacology-based analysis and experimental validation. By using the Bioinformatics Analysis Tool Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM) database, we confirmed the correlation between XQLD and asthma, and we screened 1338 potential target genes of Mahuang and Guizhi, the most active herbs in XQLD. By overlapping “Childhood asthma-related genes” of DisGeNET database, we identified 58 intersecting genes of Childhood asthma and 1338 target genes of Mahuang and Guizhi. The intersecting genes were used to construct the protein-to-protein interaction (PPI) and performed Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. GO enrichment analysis demonstrated 359 Biological Process terms, 16 Cellular Component terms, and 26 Molecular Function terms. Meantime, 75 terms of KEGG signaling pathway were involved in enrichment analysis. These candidates showed a significant correlation with inflammatory response and positive regulation of tyrosine phosphorylation of STAT protein. In addition, XQLD treatment significantly upregulated serum IFN-γ expression, and downregulated serum IL-6 expression of CVA mice. XQLD treatment significantly inhibited phosphorylation of STAT3 in bronchial-lung tissues. Our data suggest that XQLD effectively alleviated bronchial-lung tissue damage in CVA mice and inhibited the body inflammatory response by regulating IL-6/STAT3 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Xiaoqinglong decoction suppresses childhood cough variant asthma and inhibited the body inflammatory response by regulating IL-6/STAT3 signalling pathway

Ren,

Li,

Zhang

et al. 2023

Annals of Medicine &Amp; Surgery

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“…The latter include cysteinil-leukotriene antagonists and inhaled corticosteroids, which are given regularly alone or combined. The leukotriene antagonists, such as montelukast, can be used as a stand-alone maintenance therapy, especially in patients with milder asthma, in variant forms of asthma, in asthma with aspirin sensitivity or in exercise-induced bronchospasm [3]. Desloratadine is an antihistamine compound that has been tested for its effectiveness on early asthma reaction alone and combined with montelukast [2].…”

Section: Introductionmentioning

confidence: 99%

Effects of montelukast-desloratadine combination on early and late asthma responses

Antoniu

2009

Expert Opinion on Pharmacotherapy

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Inhaled corticosteroids for subacute and chronic cough in adults

Johnstone

Chang

Fong

et al. 2013

Cochrane Database of Systematic Reviews

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BackgroundPersistent cough is a common clinical problem. Despite thorough investigation and empirical management, a considerable proportion of those people with subacute and chronic cough have unexplained cough, for which treatment options are limited. While current guidelines recommend inhaled corticosteroids (ICS), the research evidence for this intervention is conflicting. ObjectivesTo assess the effects of ICS for subacute and chronic cough in adults. Search methodsWe searched the Cochrane Airways Group Register of Trials, Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and ClinicalTrials.gov in December 2012 and conducted handsearches. Selection criteriaTwo authors independently assessed all potentially relevant trials. All published and unpublished randomised comparisons of ICS versus placebo in adults with subacute or chronic cough were included. Participants with known chronic respiratory disease and asthma were excluded. Studies of cough-variant asthma and eosinophilic bronchitis were eligible. Data collection and analysisTwo authors independently extracted data pertaining to pre-defined outcomes. The primary outcome was the proportion of participants with clinical cure or significant improvement (over 70% reduction in cough severity measure) at follow up (clinical success). The secondary outcomes included proportion of participants with clinical cure or over 50% reduction in cough severity measure at follow up, mean change in cough severity measures, complications of cough, biomarkers of inflammation and adverse effects. We requested additional data from study authors.1 Inhaled corticosteroids for subacute and chronic cough in adults (Review)

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Pharmacotherapy of cough-variant asthma

Cited by 12 publications

References 52 publications

Xiaoqinglong decoction suppresses childhood cough variant asthma and inhibited the body inflammatory response by regulating IL-6/STAT3 signalling pathway

Xiaoqinglong decoction suppresses childhood cough variant asthma and inhibited the body inflammatory response by regulating IL-6/STAT3 signalling pathway

Effects of montelukast-desloratadine combination on early and late asthma responses

Inhaled corticosteroids for subacute and chronic cough in adults

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