Selective electrochemiluminescent sensing of saccharides using boronic acid-modified coreactant

Abstract

We report a strategy for modulating the electrogenerated chemiluminescence (ECL) response by integrating a boronic acid to the chemical structure of coreactants. Excellent selectivity for d-glucose was achieved by tuning the linker length of a bis-boronic acid amine coreactant.

Recent Advances in Electrochemiluminescence Analysis

“…Sojic et al designed and prepared a series of amine based coreactants integrating boronic acid function as receptor units. 103 They demonstrated that the recognition of the saccharide could modify both the structure and the reactivity of the coreactant and thus the resulting ECL emission. Besides, excellent differential selectivity for D-glucose and D-fructose was achieved by tuning the linker length of a bis-boronic acid amine coreactant.…”

Theory and Simulation for Optimising Electrogenerated Chemiluminescence from Tris(2,2′‐bipyridine)‐ruthenium(II)‐Doped Silica Nanoparticles and Tripropylamine

“…Thirdly, ECL techniques generally involve simpler preparation procedures and higher speed of analysis than other techniques with analogous sensitivity. For example, in some circumstances, the analyte itself may be used as the co‐reactant (e. g. amino acids, like many other biological amines), leading to few‐reagents analyses …”

“…For example, in some circumstances, the analyte itself may be used as the co-reactant (e. g. amino acids, like many other biological amines), leading to few-reagents analyses. [14][15][16] The specificity and selectivity of the detection process may be ensured by implementing the ECL system in the detection modulus of separation techniques like HPLC or electrophoresis, including microfluidic-driven columns, thus enlarging the analytical possibilities. Concerning analyses of large biomole-cules (nucleic acids, proteins, etc.)…”

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

“… 87 Disruption of Hsp90 function has been shown to promote HIF-1α degradation via a novel, oxygen-independent E3 ubiquitin ligase and diminishes HIF-1α transcriptional activity. 88 HIF-1α heterodimers may also not acquire the proper conformation and therefore fail to recruit cofactors important for HIF-1-mediated transcriptional activity. 89 The first Hsp90 inhibitor was the natural product, geldanamycin ( Fig.…”

“…89 The first Hsp90 inhibitor was the natural product, geldanamycin ( Fig. 3e ), 88 which exerted its inhibitory activity by competing with the ATP binding site. Another Hsp90 inhibitor, ganetespib ( Fig.…”