Selective detection of gasotransmitters using fluorescent probes based on transition metal complexes

Alday, Julieta Ruth; Mazzeo, Agostina; Suárez, Sebastián

doi:10.1016/j.ica.2020.119696

Cited by 24 publications

(16 citation statements)

References 240 publications

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Section: Hno Detection Methodsmentioning

confidence: 99%

“…204 For more detail on the structures and mechanism of action of these probes, the reader is referred to a recent review which summarizes the detection of HNO and other gasotransmitters using these fluorescent tools. 205 In summary, the biological compatibility shown by fluorescent probes and electrochemical sensors give them an advantage for performing in vivo measurements, while MIMS requires the use of complementary techniques to ensure the unequivocal detection of HNO. On the other hand, the fact that most of the fluorogenic probes are based on the one-electron reducing nature of HNO can lead to possible interferences from biological reducing agents such as thiols or ascorbate.…”

Section: 22mentioning

confidence: 99%

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Azanone (HNO): generation, stabilization and detection

et al. 2021

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Section: Hno Detection Methodsmentioning

confidence: 99%

Section: 22mentioning

confidence: 99%

Azanone (HNO): generation, stabilization and detection

et al. 2021

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“…Therefore, it is possible to design transition metal-based fluorescent probes to recognize biological macromolecules tagged with isocyanides through their coordination. Although there is no report on such applications yet, there are many related researches to detect carbon monoxides with transition metal-derived fluorescent probes ( Alcarazo et al, 2009 ; Yuan et al, 2013 ; Kos and Plenio, 2015 ; Alday et al, 2020 ). As isoelectronic with carbon monoxide ( Figure 8A ), isocyanide may also be used as a ligand which can be recognized by such fluorescent probes to achieve the non-covalent fluorescent labeling of biomacromolecules ( Figure 8B ).…”

Section: Strategy 3: Isocyanide As a Coordination Ligand For Transition Metalsmentioning

confidence: 99%

Isocyanides: Promising Functionalities in Bioorthogonal Labeling of Biomolecules

2021

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Isocyanides have drawn increasing attention in biological applications due to their attractive properties and unique reactivities, which can undergo various reactions, such as multicomponent reactions, α-addition reactions, [4 + 1] cycloaddition reactions, and the reaction scope keeps expanding. In addition to acting as reactants for the preparation of structurally interesting and diverse N-heterocycles or peptidomimetics, this type of functionality may be a good choice in the labeling and modulation of biomolecules due to the high biocompatibility and small size to minimize modifications on the parent molecule. It has been demonstrated that isocyanides can participate in biomolecule labeling through three strategies, including the two-component bioorthogonal reaction, multicomponent reaction, and metal chelation. Among them, the isocyanide-tetrazine reaction has been better studied recently, augmenting the potency of isocyanide as a bioorthogonal handle. This review will focus on the recent progress in isocyanide chemistry for labeling of biomolecules. Meanwhile, methods to introduce isocyano groups into biomacromolecules are also described to facilitate wider applications of this unique functionality.

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“…2 Transition metal complexes have sparked interest due to their potential applications in antitumor drugs. 3,4 In organisms, DNA is the main genetic material and the carrier of genetic information. 5 It can store and transmit genetic information.…”

Section: Introductionmentioning

confidence: 99%