Azanone (HNO): generation, stabilization and detection

Gallego, Cecilia Mariel; Mazzeo, Agostina; Vargas, Paola; Suárez, Sebastián; Pellegrino, Juan; Doctorovich, Fabio

doi:10.1039/d1sc02236a

Cited by 22 publications

(16 citation statements)

References 197 publications

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“…It has also been shown to be easily produced from by mild, biologically relevant reducing agents. [132] Hemoproteins are one of the main biological targets of these small molecules and heme {FeNO} [6][7][8] adducts have become a particularly interesting object of study from a bioinorganic point of view.…”

Section: Discussionmentioning

confidence: 99%

Front Cover: Structure and Reactivity of NO/NO⁺/NO⁻ Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

et al. 2021

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The Front Cover shows the two main types of ligands reviewed: pincer ligands and porphyrins. Out of the broad chemistry reported in both fields, we have reported the joint effect of either type of ligands and nitric oxide (and its congener, azanone), depicted at the center, in the overlapping area of the two hexagons. In the background, the main types of characterization techniques and reactivities and structures relevant for these complexes are portrayed. More information can be found in the Review by J. Pellegrino, F. Doctorovich and co‐workers.

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Section: Discussionmentioning

confidence: 99%

Front Cover: Structure and Reactivity of NO/NO⁺/NO⁻ Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

et al. 2021

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“…Cimlanod is a nitroxyl anion donor. 56 Under aerobic conditions nitroxyl anion may form peroxynitrite, 57,58 a toxic radical known to depress myocardial performance. 59 Peroxynitrite formation may explain the absence of sustained hemodynamic effects on termination of Cimlanod infusions in ADHF patients.…”

Section: Clinical Trials Proposed To Evaluate Gtn In Gsh In the Treat...mentioning

confidence: 99%

Nitric Oxide Is the Cause of Nitroglycerin Tolerance: Providing an Old Dog New Tricks for Acute Heart Failure

Kaesemeyer¹,

Suvorava

2022

J Cardiovasc Pharmacol Ther

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Our paper highlights the past 50 years of research focusing solely on tolerance involving nitroglycerin (glyceryl trinitrate, GTN). It also identifies and discusses inconsistencies in previous mechanistic explanations that have failed to provide a way to administer GTN continuously, free of limitations from tolerance and without the requirement of a nitrate-free interval. We illustrate, for the first time in 135 years, a mechanism whereby nitric oxide, the mediator of vasodilation by GTN, may also be the cause of tolerance. Based on targeting superoxide from mitochondrial complex I, uncoupled by glutathione depletion in response to nitric oxide from GTN, a novel unit dose GTN formulation in glutathione for use as a continuous i.v. infusion has been proposed. We hypothesize that this will reduce or eliminate tolerance seen currently with i.v. GTN. Finally, to evaluate the new formulation we suggest future studies of this new formulation for the treatment of acute decompensated heart failure.

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“…Other small nitrogen species also present biologically relevant reactivity, such as nitroxyl (NO – or HNO, the one-electron reduction products of NO • ), the nitrosonium cation (NO + ), and peroxynitrite (ONOO – ). In particular, nitroxyl has recently been established to produce its own physiological effectsboth similar and distinct from those of NO • and though it could be produced from different metabolites, the question of its biosynthesis remains unsolved …”

Section: Introductionmentioning

confidence: 99%

“…In particular, nitroxyl has recently been established to produce its own physiological effectsboth similar and distinct from those of NO • and though it could be produced from different metabolites, the question of its biosynthesis remains unsolved. 1 Biologically relevant sulfur species, on the other hand, consist mainly of thiols, as in cysteine (Cys, Figure 1a) and methionine (Met, Figure 1b) amino acids in proteins or as the antioxidant tripeptide glutathione (GSH, Figure 1c).…”

Section: ■ Introductionmentioning

confidence: 99%

H₂S/Thiols, NO^•, and NO^–/HNO: Interactions with Iron Porphyrins

et al. 2022

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In the past decade, gasotransmitters NO• and H2S have been thoroughly studied in biological contexts, as their biosynthesis and physiological effects became known. Moreover, an additional intricate crosstalk reaction scheme between these compounds and related species is thought to exist as part of the cascade signaling processes in physiological conditions. In this context, heme enzymes, as modeled by iron porphyrins, play a central role in catalyzing the key interconversions involved. In this work, iron porphyrin interactions with sulfide and nitric-oxide-related species are described. The stability and reactivity of mixed ternary systems are also described, and future perspectives are discussed.

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Azanone (HNO): generation, stabilization and detection

Abstract: HNO (nitroxyl, azanone), joined the ‘biologically relevant reactive nitrogen species’ family in the 2000s. Azanone is impossible to store due to its high reactivity and inherent low stability. Consequently, its...

Cited by 22 publications

References 197 publications

Front Cover: Structure and Reactivity of NO/NO⁺/NO⁻ Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

Front Cover: Structure and Reactivity of NO/NO⁺/NO⁻ Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

Nitric Oxide Is the Cause of Nitroglycerin Tolerance: Providing an Old Dog New Tricks for Acute Heart Failure

H₂S/Thiols, NO^•, and NO^–/HNO: Interactions with Iron Porphyrins

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Azanone (HNO): generation, stabilization and detection

Abstract: HNO (nitroxyl, azanone), joined the ‘biologically relevant reactive nitrogen species’ family in the 2000s. Azanone is impossible to store due to its high reactivity and inherent low stability. Consequently, its...

Cited by 22 publications

References 197 publications

Front Cover: Structure and Reactivity of NO/NO+/NO− Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

Front Cover: Structure and Reactivity of NO/NO+/NO− Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

Nitric Oxide Is the Cause of Nitroglycerin Tolerance: Providing an Old Dog New Tricks for Acute Heart Failure

H2S/Thiols, NO•, and NO–/HNO: Interactions with Iron Porphyrins

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Product

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Front Cover: Structure and Reactivity of NO/NO⁺/NO⁻ Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

Front Cover: Structure and Reactivity of NO/NO⁺/NO⁻ Pincer and Porphyrin Complexes (Eur. J. Inorg. Chem. 46/2021)

H₂S/Thiols, NO^•, and NO^–/HNO: Interactions with Iron Porphyrins