Selective Colorimetric Detection of Hydrogen Sulfide Based on Primary Amine-Active Ester Cross-Linking of Gold Nanoparticles

Abstract

Hydrogen sulfide (H2S) is a highly toxic environmental pollutant and also an important gaseous transmitter. Therefore, selective detection of H2S is very important, and visual detection of it with the naked eye is preferred in practical applications. In this study, thiolated azido derivates and active esters functionalized gold nanoparticles (AE-AuNPs)-based nanosensors have been successfully prepared for H2S perception. The sensing principle consists of two steps: first, H2S reduces the azide group to a primary amine; second, a cross-linking reaction between the primary amine and active ester induces the aggregation of AuNPs. The AE-AuNPs-based nanosensors show high selectivity toward H2S over other anions and thiols due to the specific azide-H2S chemistry. Under optimal conditions, 0.2 μM H2S is detectable using a UV-vis spectrophotometer, and 4 μM H2S can be easily detected by the naked eye. In addition, the practical application of the designed nanosensors was evaluated with lake water samples.

Manganese Dioxide Nanosheets‐Induced Oxidation of Dopamine for Colorimetric Sensing of Hydrogen Sulfide

“…However, the application of inorganic nanomaterials for H 2 S sensing is rare. There are a few assays for detection of H 2 S based on inorganic nanoparticles, which involve gold nanoparticles (AuNPs) and silver sulfide (Ag 2 S) nanoparticles ,. They are based on the aggregation of gold nanoparticles (AuNPs) induced by H 2 S or the in‐suit formation of Ag 2 S nanoparticles in the presence of H 2 S, leading to a color change.…”

“…Specially, fluorescent methods have been widely reported due to their high sensitivity and low background signal. The fluorescent methods always require various organic fluorophores, and the detection mechanism is based on H 2 S‐involved nucleophilic addition, H 2 S‐mediated azide reduction, and copper‐sulfide precipitation . For instance, a rapid detection of H 2 S can be realized by using a probe, and it is prepared by connecting a coumarin fluorophore and an indolenium block through an ethylene group according to the nucleophilic addition of indolenium C‐2 atom and H 2 S .…”

Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

“…Because of the low-toxic, chemically stable and easy functionalization, Au-based nanomaterials, including nanospheres, nanorods, nanoshells, and nanocages, have been widely explored for biomedical applications [23][24][25][26][27][28][29]. Due to the excellent photoabsorption and thermal conductivity of Au, Au-based nanomaterials are mostly employed as photothermal agents [30].…”

Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents

“…With the great advance in synthetic strategies, researchers are capable of preparing a variety of gold nanoparticles including nanospheres, nanorods, nanoshells and nanocages [42,43,44,45,46,47]. With proper post-functionalization, gold nanoparticles have been demonstrated to be promising agents for cancer therapy.…”