Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

Yang, Nan; Xiao, Wanyue; Song, Xuejiao; Wang, Wenjun; Dong, Xiaochen

doi:10.1007/s40820-019-0347-0

Cited by 213 publications

(152 citation statements)

References 73 publications

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“…The photoactivity of ZnPc was restored upon disaggregation and light irradiation. As cancer cells usually have upregulated H 2 O 2 , [16] the released Fe 3+ could promote catalase‐like reaction with H 2 O 2 to generate oxygen that could enhance the photodynamic action in hypoxic cancer cells [11] . Moreover, ACF could inhibit the HIF‐1 α/β dimerization and block the pathways promoting the growth of tumor, resulting in further damage to the hypoxic cancer cells through a different mechanism [17] .…”

Section: Introductionmentioning

confidence: 99%

Ferric Ion Driven Assembly of Catalase‐like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

Sun

Zhao

et al. 2020

Angewandte Chemie

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Af acile approach to assemble catalase-like photosensitizing nanozymes with aself-oxygen-supplying ability was developed. The process involved Fe 3+-driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding az inc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1(HIF-1) inhibitor acriflavine (ACF) during the Fe 3+-promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly.The released Fe 3+ could catalyze the transformation of H 2 O 2 enriched in cancer cells to oxygen efficiently,therebya meliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc-Cys/ Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc-Cys/Fe@Pc,d emonstrating the synergistic effect of ZnPc and ACF.

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Section: Introductionmentioning

confidence: 99%

Ferric Ion Driven Assembly of Catalase‐like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

Sun

Zhao

et al. 2020

Angewandte Chemie

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“…The results of our group and numerous other studies show that ROS could be used as a target or biosignature for the treatment of various diseases (Huang et al, 2017 , 2020 ; Mei et al, 2018 ; Lai et al, 2019 ; He et al, 2020 ; Yang et al, 2020a , c ; Zhao et al, 2020 ). Reactive oxygen species–responsive materials refers to materials capable of responding to those elevated ROS, such as H 2 O 2 , O 2·− , 1 O 2 , and so on.…”

Section: Mechanisms and Effects Of Abnormal Ros Levels On Oxidative Smentioning

confidence: 54%

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Liu

Chen

et al. 2020

Front. Chem.

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Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nanotechnology has been broadly applied in the field of biomedicine leading to the progress of ROS-responsive nanoparticles. In this review, we focused on the production and physiological/pathophysiological impact of ROS. Particular emphasis is put on the mechanisms and effects of abnormal ROS levels on oxidative stress diseases, including cancer, inflammatory disease, and neurodegenerative diseases. Finally, we summarized the potential biomedical applications of ROS-responsive nanocarriers in these oxidative stress diseases. We provide insights that will help in the designing of new ROS-responsive nanocarriers for various applications.

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“…H 2 O 2 is an important cell signaling molecule that plays a variety of regulatory roles in organisms, including recruiting leukocytes and maintaining redox homeostasis. [131] The production process of H 2 O 2 under physiological conditions is that the superoxide ions produced by mitochondria are catalyzed by overexpressed superoxide dismutase (SOD). Compared with normal cells, the levels of H 2 O 2 in tumor cells are significantly increased.…”

Section: Other Activationmentioning

confidence: 99%

“…[132] Because the abnormality of H 2 O 2 can promote the development of many diseases through oxidative stress, especially tumors, H 2 O 2 could be served as a promising indicator for tumor diagnosis. [131] Liang et al prepared a H 2 O 2 -activated phototherapy nanosystem. [133] They first synthesized gambogic acid grafted HA (HA-GA), that an amphiphilic prodrug sensitive to ROS.…”

Section: Other Activationmentioning

confidence: 99%

Recent Progress in the Development of Multifunctional Nanoplatform for Precise Tumor Phototherapy

Liu

Shi

Nie

et al. 2020

Adv Healthcare Materials

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Phototherapy, including photodynamic therapy and photothermal therapy, mainly relies on phototherapeutic agents (PAs) to produce heat or toxic reactive oxygen species (ROS) to kill tumors. It has attracted wide attention due to its merits of noninvasive properties and negligible drug resistance. However, the phototoxicity of conventional PAs is one of the main challenges for its potential clinical application. This is mainly caused by the uncontrolled distribution of PA in vivo, as well as the inevitable damage to healthy cells along the light path. Ensuring the generation of ROS or heat specific at tumor site is the key for precise tumor phototherapy. In this review, the progress of targeted delivery of PA and activatable phototherapy strategies based on nanocarriers for precise tumor therapy is summarized. The research progress of passive targeting, active targeting, and activatable targeting strategies in the delivery of PA is also described. Then, the switchable nanosystems for tumor precise phototherapy in response to tumor microenvironment, including pH, glutathione (GSH), protein, and nucleic acid, are highlighted. Finally, the challenges and opportunities of nanocarrier‐based precise phototherapy are discussed for clinical application in the future.

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Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

Cited by 213 publications

References 73 publications

Ferric Ion Driven Assembly of Catalase‐like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

Ferric Ion Driven Assembly of Catalase‐like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Recent Progress in the Development of Multifunctional Nanoplatform for Precise Tumor Phototherapy

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