Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Liu, Jinggong; Li, Yongjin; Chen, Song; Lin, Yongpeng; Lai, Haoqiang; Chen, Bolai; Chen, Tianfeng

doi:10.3389/fchem.2020.00838

Cited by 39 publications

(29 citation statements)

References 204 publications

(251 reference statements)

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“…However, conventional chemotherapy agents suffer from a lack of aqueous solubility, lack of selectivity, and are subject to multidrug resistance. Nanotherapeutics are rapidly developing to overcome the limitations of traditional drug delivery systems (Dong et al, 2019 ; He et al, 2020 ; Liu et al, 2020 ). Common anticancer drugs damage peripheral tissues and cells other than the targeted tissue, and here, using herbal medicines could be a safer alternative choice to avoid harmful side effects (Pavan et al, 2016 ; Unlu et al, 2016 ; Oun et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment

et al. 2021

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Nanogels (Ng) are crosslinked polymer-based hydrogel nanoparticles considered to be next-generation drug delivery systems due to their superior properties, including high drug loading capacity, low toxicity, and stimuli responsiveness. In this study, dually thermo-pH-responsive plasmonic nanogel (AuNP@Ng) was synthesized by grafting poly (N-isopropyl acrylamide) (PNIPAM) to chitosan (CS) in the presence of a chemical crosslinker to serve as a drug carrier system. The nanogel was further incorporated with gold nanoparticles (AuNP) to provide simultaneous drug delivery and photothermal therapy (PTT). Curcumin's (Cur) low water solubility and low bioavailability are the biggest obstacles to effective use of curcumin for anticancer therapy, and these obstacles can be overcome by utilizing an efficient delivery system. Therefore, curcumin was chosen as a model drug to be loaded into the nanogel for enhancing the anticancer efficiency, and further, its therapeutic efficiency was enhanced by PTT of the formulated AuNP@Ng. Thorough characterization of Ng based on CS and PNIPAM was conducted to confirm successful synthesis. Furthermore, photothermal properties and swelling ratio of fabricated nanoparticles were evaluated. Morphology and size measurements of nanogel were determined by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Nanogel was found to have a hydrodynamic size of ~167 nm and exhibited sustained release of curcumin up to 72 h with dual thermo-pH responsive drug release behavior, as examined under different temperature and pH conditions. Cytocompatibility of plasmonic nanogel was evaluated on MDA-MB-231 human breast cancer and non-tumorigenic MCF 10A cell lines, and the findings indicated the nanogel formulation to be cytocompatible. Nanoparticle uptake studies showed high internalization of nanoparticles in cancer cells when compared with non-tumorigenic cells and confocal microscopy further demonstrated that AuNP@Ng were internalized into the MDA-MB-231 cancer cells via endosomal route. In vitro cytotoxicity studies revealed dose-dependent and time-dependent drug delivery of curcumin loaded AuNP@Ng/Cur. Furthermore, the developed nanoparticles showed an improved chemotherapy efficacy when irradiated with near-infrared (NIR) laser (808 nm) in vitro. This work revealed that synthesized plasmonic nanogel loaded with curcumin (AuNP@Ng/Cur) can act as stimuli-responsive nanocarriers, having potential for dual therapy i.e., delivery of hydrophobic drug and photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment

et al. 2021

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“…Nanocarriers' wide range of biomedical applications makes them prone to constant evaluation and improvement at an accelerated rate over the years. Despite their primary use as carriers of anti-neoplastic drugs, there are many other applications in diseases such as diabetes, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease), chronic inflammations, inflammatory diseases (inflammatory bowel disease), venous thromboembolism [94,95], and others that are summarized in Figure 3.…”

Section: Biomedical Applications Of Nanocarriersmentioning

confidence: 99%

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

Milan

Mioc

Prodea

et al. 2022

IJMS

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The last decade has witnessed a sustained increase in the research development of modern-day chemo-therapeutics, especially for those used for high mortality rate pathologies. However, the therapeutic landscape is continuously changing as a result of the currently existing toxic side effects induced by a substantial range of drug classes. One growing research direction driven to mitigate such inconveniences has converged towards the study of natural molecules for their promising therapeutic potential. Triterpenes are one such class of compounds, intensively investigated for their therapeutic versatility. Although the pharmacological effects reported for several representatives of this class has come as a well-deserved encouragement, the pharmacokinetic profile of these molecules has turned out to be an unwelcomed disappointment. Nevertheless, the light at the end of the tunnel arrived with the development of nanotechnology, more specifically, the use of liposomes as drug delivery systems. Liposomes are easily synthesizable phospholipid-based vesicles, with highly tunable surfaces, that have the ability to transport both hydrophilic and lipophilic structures ensuring superior drug bioavailability at the action site as well as an increased selectivity. This study aims to report the results related to the development of different types of liposomes, used as targeted vectors for the delivery of various triterpenes of high pharmacological interest.

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“…Strategies promoting controlled H 2 O 2 delivery may include the utilization of nano systems, diffusible molecules, and stimulus-sensitive compounds (195)(196)(197)(198). Stimulus-responsive materials are particularly attractive to target specific disease-associated microenvironments such as changes in pH due to inflammation (189,199,200). In accord, one can imagine the development of redox-sensitive materials actively releasing appropriate oxidants until a certain threshold is achieved and the system self-inactivates.…”

Section: Use Of Hydrogen Peroxidementioning

confidence: 99%

Raising the ‘Good’ Oxidants for Immune Protection

Dumas

Knaus

2021

Front. Immunol.

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Redox medicine is a new therapeutic concept targeting reactive oxygen species (ROS) and secondary reaction products for health benefit. The concomitant function of ROS as intracellular second messengers and extracellular mediators governing physiological redox signaling, and as damaging radicals instigating or perpetuating various pathophysiological conditions will require selective strategies for therapeutic intervention. In addition, the reactivity and quantity of the oxidant species generated, its source and cellular location in a defined disease context need to be considered to achieve the desired outcome. In inflammatory diseases associated with oxidative damage and tissue injury, ROS source specific inhibitors may provide more benefit than generalized removal of ROS. Contemporary approaches in immunity will also include the preservation or even elevation of certain oxygen metabolites to restore or improve ROS driven physiological functions including more effective redox signaling and cell-microenvironment communication, and to induce mucosal barrier integrity, eubiosis and repair processes. Increasing oxidants by host-directed immunomodulation or by exogenous supplementation seems especially promising for improving host defense. Here, we summarize examples of beneficial ROS in immune homeostasis, infection, and acute inflammatory disease, and address emerging therapeutic strategies for ROS augmentation to induce and strengthen protective host immunity.

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Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Cited by 39 publications

References 204 publications

Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment

Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

Raising the ‘Good’ Oxidants for Immune Protection

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