Selective adenosine-5′-monophosphate uptake by water-compatible molecularly imprinted polymer

Breton, Florent; Delépée, Raphaël; Jégourel, Damien; Deville‐Bonne, Dominique; Agrofoglio, Luigi A.

doi:10.1016/j.aca.2008.04.025

Cited by 37 publications

(27 citation statements)

References 31 publications

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“…Even if accuracy was not good, interactions on MIP can be considered much higher than on NIP suggesting that functional monomer formed tight cavities around template molecule and participates to recognition and number of interaction sites was of the same order for both MIP and NIP. Compared to the covalent approach that we developed previously [17], affinity and number of cavities were lower. This was in good agreement with the relation between bond energies of boronate ester covalent bond and ionic bond.…”

Section: Isothermmentioning

confidence: 94%

“…In a previous work, we showed that a strong interaction was needed to bind AMP with imprinted polymers [17]. However, we did not use AMP as template but silylated adenosine as dummy template.…”

Section: Choice Of the Phosphate Selective Monomermentioning

confidence: 99%

“…Indeed acrylamide was able to interact with ribose and nucleobase moieties, classically needing three or four equivalents of acrylamide [17]. However, in many cases, good imprinting required an excess of functional monomers.…”

Section: Effect Of Ionic Strength According To the Polymer Formulationmentioning

confidence: 99%

“…In these cases the phosphate group of AMP was not recognized. We have previously successfully developed an MIP for AMP by imprinting 59-O-tert-butyldimethylsilyladenosine [17]. The imprinting was favored by the modification of AMP by a hydrophobic group.…”

Section: Introductionmentioning

confidence: 99%

“…We studied the interactions of different functional monomers that could interact with the phosphate functionality. Acrylamide was conserved for interactions with the nucleobase and the ribose moieties as previously shown [17]. MIPs and corresponding nonimprinted polymer (NIP) will be evaluated as an SPE sorbent.…”

Section: Introductionmentioning

confidence: 99%

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Molecular imprinting of AMP by an ionic‐noncovalent dual approach

Breton¹,

Delépée²,

Agrofoglio³

2009

J of Separation Science

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In order to mimic recognition properties of adenylate kinase, molecularly imprinted polymers (MIPs) were prepared for adenosine 5'-monophosphate (AMP), a substrate of the enzyme. Different functional monomers interacting with the phosphate moiety were tested, and the MIP giving the best specific binding of AMP was composed with one equivalent of 2-(dimethylamino)ethyl methacrylate and ten equivalents of acrylamide compared to AMP. Packed into solid phase cartridge, this polymer showed similar characteristics than the enzyme, since it was specific for AMP toward other nucleotides.

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Section: Isothermmentioning

confidence: 94%

Section: Choice Of the Phosphate Selective Monomermentioning

confidence: 99%

Section: Effect Of Ionic Strength According To the Polymer Formulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Molecular imprinting of AMP by an ionic‐noncovalent dual approach

Breton¹,

Delépée²,

Agrofoglio³

2009

J of Separation Science

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The Use of Molecularly Imprinted Polymers for Sampling and Sample Preparation

Sellergren

Martín‐Esteban

2010

Handbook of Sample Preparation

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Preparation of water‐compatible molecularly imprinted polymers for caffeine with a novel ionic liquid as a functional monomer

Luo

Dong

Luo

et al. 2012

J of Applied Polymer Sci

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Water-compatible molecularly imprinted polymers (MIPs) for caffeine were synthesized in aqueous medium with a new functional monomer, 1-(a-methyl acrylate)-3-methylimidazolium bromide (1-MA-3MI-Br), which had p-p and hydrogen-bonding interactions. Caffeine-imprinted polymers were prepared in suspension polymerization with 1-MA-3MI-Br and methacrylic acid (MAA), which only had hydrogen bonding, as a functional monomer. For the specific binding characteristics of the new functional monomer 1-MA-3MI-Br, the adsorption capacity and relative separation factor (b) of MIPs for caffeine were significantly enhanced. The maximum adsorption capacities of 1-MA-3MI-Br-MIP and MAA-MIP imprinted microspheres for caffeine were 53.80 and 28.90 lmol/g, respectively. Moreover, the relative separation factors were measured by comparison of the separation characteristics under competitive adsorption conditions. The results showed that the b of MAA-MIP for caffeine relative to theophylline was only 1.65; this showed a very poor recognition selectivity for caffeine, but b of 1-MA-3MI-Br-MIP for caffeine with respect to theophylline was remarkably enhanced to 3.19; this showed an excellent recognition selectivity and binding affinity toward caffeine molecules in an aqueous environment.

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Selective adenosine-5′-monophosphate uptake by water-compatible molecularly imprinted polymer

Cited by 37 publications

References 31 publications

Molecular imprinting of AMP by an ionic‐noncovalent dual approach

Molecular imprinting of AMP by an ionic‐noncovalent dual approach

The Use of Molecularly Imprinted Polymers for Sampling and Sample Preparation

Preparation of water‐compatible molecularly imprinted polymers for caffeine with a novel ionic liquid as a functional monomer

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