Selection of phospholipids to design liposome preparations with high skin penetration-enhancing effects

Sakdiset, Pajaree; Okada, Akie; Todo, Hiroaki; Sugibayashi, Kenji

doi:10.1016/j.jddst.2017.11.021

Cited by 29 publications

(14 citation statements)

References 23 publications

(23 reference statements)

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“…The choice of design parameters was determined by previously reported studies. The type of phospholipids used has been investigated in several studies and has been reported to produce liposomal vesicles with different properties . Therefore, natural and synthetic phospholipids (EPC and DMPC) were investigated in this study.…”

Section: Resultsmentioning

confidence: 99%

“…The type of phospholipids used has been investigated in several studies and has been reported to produce liposomal vesicles with different properties. [28] Therefore, natural and synthetic phospholipids (EPC and DMPC) were investigated in this study. Additionally, it was reported that the surfactant type and concentration can also affect transfersome size and % EE.…”

Section: Transfersome Optimisation and Taguchi Doe Analysismentioning

confidence: 99%

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Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic

Bnyan

Khan

Ehtezazi

et al. 2019

Journal of Pharmacy and Pharmacology

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Objective To investigate the effect of formulation parameters on the preparation of transfersomes as sustained‐release delivery systems for lidocaine and to develop and validate a new high‐performance liquid chromatography (HPLC) method for analysis. Method Taguchi design of experiment (DOE) was used to optimise lidocaine‐loaded transfersomes in terms of phospholipid, edge activator (EA) and phospholipid : EA ratio. Transfersomes were characterised for size, polydispersity index (PDI), charge and entrapment efficiency (%EE). A HPLC method for lidocaine quantification was optimised and validated using a mobile phase of 30%v/v PBS (0.01 m) : 70%v/v Acetonitrile at a flow rate of 1 ml/min, detected at 255 nm with retention time of 2.84 min. The release of lidocaine from selected samples was assessed in vitro. Key findings Transfersomes were 200 nm in size, with PDI ~ 0.3. HPLC method was valid for linearity (0.1–2 mg/ml, R2 0.9999), accuracy, intermediate precision and repeatability according to ICH guidelines. The %EE was between 44% and 56% and dependent on the formulation parameters. Taguchi DOE showed the effect of factors was in the rank order : lipid : EA ratio ˃ EA type ˃ lipid type. Optimised transfersomes sustained the release of lidocaine over 24 h. Conclusion Sustained‐release, lidocaine‐loaded transfersomes were successfully formulated and optimised using a DOE approach, and a new HPLC method for lidocaine analysis was developed and validated.

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Section: Resultsmentioning

confidence: 99%

Section: Transfersome Optimisation and Taguchi Doe Analysismentioning

confidence: 99%

Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic

Bnyan

Khan

Ehtezazi

et al. 2019

Journal of Pharmacy and Pharmacology

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“…Size is an essential factor to bear in mind since smaller sizes lead to larger surface areas and subsequently to greater reactivity and control the drug's release kinetics (Samadi et al, 2020 ). According to Sakdiset et al ( 2018 ), composition and design are essential factors to consider for developing efficient nanoliposome with high skin permeation and improved performance. The research group found that 1,2-di- palmitoyl-sn-glycero-3-phosphoglycerol, sodium salt (DPPG) can be a promising phospholipid candidate for nanoliposome formulations with high skin penetration-enhancing effects.…”

Section: Influencing Factors That Affect the Nanoliposomes Performancmentioning

confidence: 99%

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Aguilar-Pérez

Avilés-Castrillo

Medina

et al. 2020

Front. Bioeng. Biotechnol.

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The necessity to develop more efficient, biocompatible, patient compliance, and safer treatments in biomedical settings is receiving special attention using nanotechnology as a potential platform to design new drug delivery systems (DDS). Despite the broad range of nanocarrier systems in drug delivery, lack of biocompatibility, poor penetration, low entrapment efficiency, and toxicity are significant challenges that remain to address. Such practices are even more demanding when bioactive agents are intended to be loaded on a nanocarrier system, especially for topical treatment purposes. For the aforesaid reasons, the search for more efficient nano-vesicular systems, such as nanoliposomes, with a high biocompatibility index and controlled releases has increased considerably in the past few decades. Owing to the stratum corneum layer barrier of the skin, the in-practice conventional/conformist drug delivery methods are inefficient, and the effect of the administered therapeutic cues is limited. The current advancement at the nanoscale has transformed the drug delivery sector. Nanoliposomes, as robust nanocarriers, are becoming popular for biomedical applications because of safety, patient compliance, and quick action. Herein, we reviewed state-of-the-art nanoliposomes as a smart and sophisticated drug delivery approach. Following a brief introduction, the drug delivery mechanism of nanoliposomes is discussed with suitable examples for the treatment of numerous diseases with a brief emphasis on fungal infections. The latter half of the work is focused on the applied perspective and clinical translation of nanoliposomes. Furthermore, a detailed overview of clinical applications and future perspectives has been included in this review.

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“…It has been many times shown that the nature of liposomes strongly in uences the behavior of incorporated molecules [35][36][37][38] . There are many reports showing the effect of tocopherols in pure lipid systems 11,21,39 .…”

Section: Antioxidant Activity Of Tocochromanols In Different Nanocarrmentioning

confidence: 99%

Antioxidant activity of vitamin E homologues in model systems

Trela-Makowej

Kruk

Szymańska

2021

Preprint

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The effect of tocopherols, tocotrienols and plastochromanol-8 in the inhibition of lipid peroxidation of liposomes prepared from natural chloroplast lipids, initiated by both water-soluble and lipid soluble azo-compounds, has been studied. In the case of tocopherols, α-tocopherol showed nearly no effect in the inhibition of lipid peroxidation, while β-, γ- and δ-tocopherols inhibited the reaction completely when it was initiated by lipid-soluble AMVN. Similar effects were observed for tocotrienol homologues. In the investigated reaction plastochromanol-8 was as effective as β-, γ- and δ-tocochromanols. When peroxidation was initiated by water-soluble AIPH in liposomes, the order and extent of inhibition was similar to those of AMVN initiator. However, in this case, α-tocopherol and α-tocotrienol showed more pronounced inhibition. When the prenyllipids were investigated in DPPH test, when incorporated into soy lipid liposomes, mixed micelles and micelles, DPPH oxidation was most pronounced in liposomes, followed by mixed micelles and micellar system. When the reaction of α-tocopherol, α-tocotrienol, plastochromanol-8 and α-tocopherol phosphate was examined in niosomes, the oxidation was most pronounced for α-tocopherol and plastochromanol-8, followed by α-tocotrienol. α-tocopherol phosphate showed no activity in this respect. The obtained results were discussed in light of the prenyllipid structures and their localization in the investigated lipid systems.

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Selection of phospholipids to design liposome preparations with high skin penetration-enhancing effects

Cited by 29 publications

References 23 publications

Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic

Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Antioxidant activity of vitamin E homologues in model systems

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