Selection of antimicrobial agents in periodontal therapy

Slots, Jørgen

doi:10.1034/j.1600-0765.2002.00004.x

Cited by 230 publications

(244 citation statements)

References 68 publications

Supporting

Mentioning

214

Contrasting

Unclassified

Order By: Relevance

“…Its broad antimicrobial activity, fast bactericidal action and nontoxicity at application concentration, has been known since many years [9]. Already in 1918 it was published that sodium hypochlorite has a higher dissolving effect on necrotic tissue than on vital one [10].…”

Section: Introductionmentioning

confidence: 99%

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

et al. 2016

View full text Add to dashboard Cite

2Objectives: The aim of the present study was to assess the antimicrobial activity of a sodium hypochlorite formulation incl. its components against bacteria associated with periodontal disease. Materials and Methods:Sodium hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl) and the activating vehicle were compared with 0.1% chlorhexidine digluconate (CHX) solution. The antimicrobial activity was proven by determination of minimal inhibitory concentrations (MIC), minimal bactericidal concentrations, and killing assays. Furthermore, the influence on formation as well as on a 4-days old 6-species biofilm was tested.Results: Except for one strain (Parvimonas micra ATCC 33270 in case of NaOCl gel) the MICs both of the CHX solution and NaOCl gel did not exceed 10% of the formulations' concentration. In general MICs of the NaOCl gel were equal as of the CHX solution against Gram-negatives but higher against Gram-positive bacteria. CHX but not NaOCl gel clearly inhibited biofilm formation, however the activity of NaOCl gel was more remarkable on a 4-d old biofilm. NaOCl killed bacteria in the biofilm and interfered with the matrix. Conclusions:The NaOCl gel acts antimicrobial in particular against Gram-negative species associated with periodontitis. Moreover, its component NaOCl hypochlorite is able to alter biofilm matrices.Clinical relevance: The NaOCl gel may represent a potential alternative for adjunctive topical antimicrobial treatment in periodontitis

show abstract

Section: Introductionmentioning

confidence: 99%

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…7 The intracanal medication mostly used for root canal disinfection is the triple antibiotic paste, 8 composed of ciprofloxacin, metronidazole, and minocycline. Even though this combination of drugs has shown to be effective against bacteria commonly found in root canals, both in vitro 8,9 and in vivo, 2,10 some shortcomings have been described, e.g., tooth discoloration, 2,11,12,13 bacterial resistance, 14,15 and allergic reactions. 16,17 More recently, demineralization of radicular dentin 18 and a toxic effect on cells from the dental pulp and apical papilla 19 have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Tissue characterization following revascularization of immature dog teeth using different disinfection pastes

et al. 2016

View full text Add to dashboard Cite

“…At temperatures under the critical one, the poloxamer solution is in the form of a low-viscosity sol, while above it, when approaching body temperature, a viscous transparent gel is formed. 6 Among the antimicrobials used for the treatment of periodontitis, metronidazole is particularly suitable due to its restricted spectrum of activity against obligate anaerobes 7 and its limited side effects, compared to those of tetracyclines, i.e., selection of multiresistant bacteria 8 and perturbation of the normal microbiota of the body.…”

Section: Introductionmentioning

confidence: 99%

Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation

Sato¹,

Fonseca²,

Ciampo

et al. 2008

Braz. oral res.

View full text Add to dashboard Cite

The aim of this investigation was to monitor metronidazole concentrations in the gingival crevicular fluid (GCF) collected from periodontal pockets of dogs after treatment with an experimental 15% metronidazole gel. Five dogs had periodontitis induced by cotton ligatures placed subgingivally and maintained for a 30-day period. After the induction period, only pockets with 4 mm or deeper received the gel. Each pocket was filled up to the gingival margin by means of a syringe with a blunt-end needle. GCF was collected in paper strips and quantified in an electronic device before and after 15 minutes, 1 h, 6 h, 24 h and 48 h of gel administration. The GCF samples were assayed for metronidazole content by means of a high performance liquid chromatography method. Concentrations of metronidazole in the GCF of the 5 dogs (mean ± SD, in µg/mL) were 0 ± 0 before gel application and 47,185.75 ± 24,874.35 after 15 minutes, 26,457.34 ± 25,516.91 after 1 h, 24.18 ± 23.11 after 6 h, 3.78 ± 3.45 after 24 h and 3.34 ± 5.54 after 48 h. A single administration of the 15% metronidazole gel released the drug in the GCF of dogs in levels several-fold higher than the minimum inhibitory concentration for some periodontopathogens grown in subgingival biofilms for up to one hour, but metronidazole could be detected in the GCF at least 48 hours after the gel application.

show abstract

Selection of antimicrobial agents in periodontal therapy

Cited by 230 publications

References 68 publications

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

Tissue characterization following revascularization of immature dog teeth using different disinfection pastes

Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation

Contact Info

Product

Resources

About