Selection of a new Mycobacterium tuberculosis H37Rv aptamer and its application in the construction of a SWCNT/aptamer/Au-IDE MSPQC H37Rv sensor

Zhang, Xiaoqing; Feng, Yue; Yao, Qiong-Qiong; He, Fengjiao

doi:10.1016/j.bios.2017.05.043

Cited by 30 publications

(17 citation statements)

References 28 publications

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“…Ligand-responsive biosensors To obtain highly sensitive and rapid detection of pathogen bacteria, aptamers have been combined with ligand-responsive biosensing devices, like quartz crystal microbalance (QCM) [62] and multichannel series piezoelectric quartz crystal (MSPQC) [63]. QCM is a sensor that can measure the quality with high sensitivity.…”

Section: Bacterial Detectionmentioning

confidence: 99%

Selection and applications of functional nucleic acids for infectious disease detection and prevention

et al. 2021

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Infectious diseases caused by pathogenic microorganisms such as viruses and bacteria pose a great threat to human health. Although a significant progress has been obtained in the diagnosis and prevention of infectious diseases, it still remains challenging to develop rapid and cost-effective detection approaches and overcome the side effects of therapeutic agents and pathogen resistance. Functional nucleic acids (FNAs), especially the most widely used aptamers and DNAzymes, hold the advantages of high stability and flexible design, which make them ideal molecular recognition tools for bacteria and viruses, as well as potential therapeutic drugs for infectious diseases. This review summarizes important advances in the selection and detection of bacterial-and virus-associated FNAs, along with their potential prevention ability of infectious disease in recent years. Finally, the challenges and future development directions are concluded.

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Section: Bacterial Detectionmentioning

confidence: 99%

Selection and applications of functional nucleic acids for infectious disease detection and prevention

et al. 2021

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“…In addition, they show high luminous intensity and excellent luminous properties, which are ideal for optical biosensing [75,76,77,78,79,80]. CNTs have only a sixth of the density of steel but are 100 times stronger, allowing their use in fabricating piezoresistive sensors [81,82,83,84]. It is also possible to synthesize CNT-based calorimetric sensors which rely on changes in the size of nanotubes caused by thermal variations [18,85].…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

“…Interdigital electrodes (IDE) of series piezoelectric quartz crystal (SPQC) have been frequently coupled with CNTs to develop piezoelectric sensors for clinical diagnosis [81,82,83,84]. Zhang et al developed an aptasensor in this way for the detection of Mycobacterium tuberculosis (H37Rv) with the help of a single-strand deoxyribonucleic acid (ssDNA) aptamer [81]. The sensor provided a linear signal in the concentration range of 1 × 10 3 –1 × 10 7 cfu mL −1 with an LOD of 100 cfu mL −1 .…”

Section: Carbon Allotrope-based Nanomaterials Applications In Healtmentioning

confidence: 99%

Nanomaterials for Healthcare Biosensing Applications

Pirzada

Altıntaş

2019

Sensors

166

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In recent years, an increasing number of nanomaterials have been explored for their applications in biomedical diagnostics, making their applications in healthcare biosensing a rapidly evolving field. Nanomaterials introduce versatility to the sensing platforms and may even allow mobility between different detection mechanisms. The prospect of a combination of different nanomaterials allows an exploitation of their synergistic additive and novel properties for sensor development. This paper covers more than 290 research works since 2015, elaborating the diverse roles played by various nanomaterials in the biosensing field. Hence, we provide a comprehensive review of the healthcare sensing applications of nanomaterials, covering carbon allotrope-based, inorganic, and organic nanomaterials. These sensing systems are able to detect a wide variety of clinically relevant molecules, like nucleic acids, viruses, bacteria, cancer antigens, pharmaceuticals and narcotic drugs, toxins, contaminants, as well as entire cells in various sensing media, ranging from buffers to more complex environments such as urine, blood or sputum. Thus, the latest advancements reviewed in this paper hold tremendous potential for the application of nanomaterials in the early screening of diseases and point-of-care testing.

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“…Zhang et al selected an aptamer specific for the H37Rv strain M. tuberculosis with a Kd of 37 ± 4 nM [ 51 ]. The research group also developed a multichannel series piezoelectric quartz crystal sensor using the selected aptamer, single-walled carbon nanotube, and gold electrode, to achieve a detection limit of 100 CFU/mL in seventy minutes.…”

Section: In Vitro Selection Of Ssdna Aptamersmentioning

confidence: 99%

Recent Progress in the Identification of Aptamers Against Bacterial Origins and Their Diagnostic Applications

Trunzo

Hong

2020

IJMS

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Aptamers have gained an increasing role as the molecular recognition element (MRE) in diagnostic assay development, since their first conception thirty years ago. The process to screen for nucleic acid-based binding elements (aptamers) was first described in 1990 by the Gold Laboratory. In the last three decades, many aptamers have been identified for a wide array of targets. In particular, the number of reports on investigating single-stranded DNA (ssDNA) aptamer applications in biosensing and diagnostic platforms have increased significantly in recent years. This review article summarizes the recent (2015 to 2020) progress of ssDNA aptamer research on bacteria, proteins, and lipids of bacterial origins that have implications for human infections. The basic process of aptamer selection, the principles of aptamer-based biosensors, and future perspectives will also be discussed.

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Selection of a new Mycobacterium tuberculosis H37Rv aptamer and its application in the construction of a SWCNT/aptamer/Au-IDE MSPQC H37Rv sensor

Cited by 30 publications

References 28 publications

Selection and applications of functional nucleic acids for infectious disease detection and prevention

Selection and applications of functional nucleic acids for infectious disease detection and prevention

Nanomaterials for Healthcare Biosensing Applications

Recent Progress in the Identification of Aptamers Against Bacterial Origins and Their Diagnostic Applications

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