Sedative and anxiolytic efficacy of Tilia americana var. mexicana inflorescences used traditionally by communities of State of Michoacan, Mexico

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

“…Previous studies reported that inflorescences of T. americana var. mexicana collected in different regions of Mexico such as Michoacan, 6 Estado de Mexico, 17 Guerrero, Hidalgo and Veracruz 7 produce anxiolytic and sedative-like effects on mice. These investigations agree with others from Latin American (T. tomentosa) and European (T. platyphyllos, T. rubra and T. argentea) species of Tilia 9,18,22 corroborating such therapeutic property of flowers and bracts.…”

“…Ambulatory activity was registered as the number of squares explored by each mouse in a 2 min lapse. 6 …”

“…In previous studies, a significant dose-dependent anxiolytic-like activity was demonstrated for methanolic and aqueous extracts of Tilia inflorescences, further glycosides of quercetin and kaempferol were characterized and suggested as the main active compounds. 6,7 It is known that the quality and quantity of secondary metabolites particularly tend to fluctuate depending on factors such as genetic drift, physiological conditions, season, and harvesting time, as well as sample preparation and analytical method. [8][9][10] Numerous investigations on the aforementioned factors have been conducted; as a result, it has been found that the phenological stage and collection site strongly influence the quantity of secondary metabolites.…”

Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

“…The anxiolytic effect of Tilia species, such as T. americana var. Mexicana, has been attributed to the presence of tiliroside (Anesini et al, 1999;Perez-Ortega et al, 2008). Phytochemical studies have demonstrated that Tilia species possess hydrocarbons, esters, aliphatic acids (Fitsiou et al, 2007), terpenoids, quercetin and kaempferol derivatives (Pietta et al, 1994), phenolic compounds, condensed tannins (Behrens et al, 2003) and a coumarin scopoletin (Arcos et al, 2006).…”

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“…INTRODUCTION: A sedative or hypnotic drug is one that reversibly depresses the activity of the central nervous system, used chiefly to induce sleep and to allay anxiety. Recent studies have shown that herbal drugs exert good sedative and hypnotic effect on the central nervous system [1][2][3] . The scientific literature has demonstrated that different extracts and compounds of onion produce significant biological effects 4 .…”