Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

Negri, Giuseppina; Santi, Daniel de; Tabach, Ricardo

doi:10.1590/s1516-05722013000200008

Cited by 42 publications

(28 citation statements)

References 30 publications

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“…1A and B. Equisetum giganteum presented fourteen phenolic compounds (two phenolic acids and twelve flavonol glycoside derivatives), while T. platyphyllos presented a more complex matrix regarding its phenolic composition, revealing the presence of thirty-three compounds (three phenolic acids, six flavan-3-ol derivatives, twenty flavonol glycoside derivatives, two flavanone and flavone derivatives). 16 Protocatechuic acid, catechin, epicatechin and Table 1 Phenolic compounds' identification and quantification in the Equisetum giganteum extract 21 In the present study, these compounds were also present in high amounts, representing 34% of the total 593, yielding two fragment ions from the consecutive loss of two deoxyhexosyl residues; it was tentatively identified as quercetin-3,7-di-O-rhamnoside, a compound commonly reported in Tilia species [27][28][29][30] 21 The observation in their fragmentation of a product ion at m/z 447, from the loss of p-coumaroyl residue (146 u) would also be coherent with that identity, as well as with the late elution, since the presence of the hydroxycinnamoyl residue implies a decrease in polarity. The detection of two peaks could be explained by the existence of trans-and cis-isomers of the p-coumaric acid, as also noted by Karioti et al 21 The most abundant peak 32 Tp can be assigned as trans-tiliroside taking into account that the form trans is the usual one for p-coumaric acid.…”

Section: Discussionsupporting

confidence: 51%

Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.

et al. 2017

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a Naturally-occurring phytochemicals have received pivotal attention in the last few years, due to the increasing evidence of biological activities. Thus, in the present study, the antioxidant, anti-inflammatory and antitumor potentials of hydroethanolic extracts rich in phenolic compounds obtained from Equisetum giganteum L. and Tilia platyphyllos Scop. were assessed and directly correlated with their content of phenolic compounds, by using HPLC-DAD-ESI/MS analysis. T. platyphyllos showed the higher bioactive potential, evaluated in terms of antioxidant (radical scavenging effects -105 μg mL −1 , reducing power -123 μg mL −1 , β-carotene bleaching inhibition -167 μg mL −1 , and lipid peroxidation inhibition -), anti-inflammatory (225 μg mL −1 inhibited 50% of nitric oxide production) and antitumor (breast -224 μg mL −1 ; lung -247 μg mL −1 ; cervical -195 μg mL −1 and hepatocellular -173 μg mL −1 carcinoma cells) activity, without having cytotoxic effects (>400 μg mL −1 ). These biological properties were positively correlated with its content and composition of phenolic compounds. Flavonoid contents were markedly higher than the content of phenolic acids, in both samples, being respectively 50.4 mg g −1 and 11.65 mg g −1 for T. platyphyllos, and 21.7 mg g −1 and 4.98 mg g −1 for E. giganteum. Moreover, while in E. giganteum extract, kaempferol-O-glucoside-O-rutinoside was the most abundant flavonoid, in T. platyphyllos extract protocatechuic acid and (−)-epicatechin were the most abundant phenolic acid and flavonoid, respectively. In relation to their content of phenolic acids, protocatechuic and caffeic acids existed in higher abundance in T. platyphyllos and E. giganteum hydroethanolic extracts, respectively.However, it would be interesting to evaluate the in vivo efficacy of both plant extracts to unveil the involved modes of action and to establish effective therapeutic doses.

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Section: Discussionsupporting

confidence: 51%

Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.

et al. 2017

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“…This difference might be due to the specific composition of the lime flavonoid fraction (quercetin and kaempferol glycosides, tiliroside, procyanidin dimer B2; Negri et al . ) as well as the presence in chamomile of the antioxidant bisabolol and its derivatives (Braga et al . ; Singh et al .…”

Section: Resultsmentioning

confidence: 99%

“…However, the results for lime and chamomile were slightly higher (recovery 107-113%) when compared with the reference method. This difference might be due to the specific composition of the lime flavonoid fraction (quercetin and kaempferol glycosides, tiliroside, procyanidin dimer B2; Negri et al 2013) as well as the presence in chamomile of the antioxidant bisabolol and its derivatives (Braga et al 2009;Singh et al 2011;Raal et al 2012). The substances mentioned above may act as interference factors in the analyzed method.…”

Section: Determination Of Total Phenolic Compounds In Infusions Of Tementioning

confidence: 99%

Determination of Total Phenolic Compounds in Common Beverages Using CdTe Quantum Dots

Dwiecki

Nogala‐Kałucka

Polewski

2016

Journal of Food Processing and Preservation

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In this study, we describe a method of total phenolic compounds determination based on CdTe quantum dot (QD) fluorescence recovery in the presence of analyte. Polyphenols present in the solution were reducing agents, acting as electron donors to the CdTe–sodium periodate system, thus leading to perturbation of the transfer of excited electrons from QD to the acceptor molecules occurring in the absence of polyphenols. Using the developed technique the polyphenol content in green tea, black tea, Pu‐Erh tea, lemon balm, peppermint, lime, chamomile, and coffee infusions was successfully determined. The limit of detection of the method amounted to 0.63 nM of (+)‐catechin equivalent, which makes this technique nearly one order of magnitude more sensitive than the commonly used Folin–Ciocalteu method. Additionally, lack of impact of interference from proteins and reducing sugars on the results makes this technique an advantageous alternative to the Folin–Ciocalteu assay. Practical Applications The developed method for total phenolic compound determination, thanks to higher specificity and a low detection limit may be a beneficial alternative to the popular Folin–Ciocalteu assay. The applications of the described technique include plant raw material and product nutritional quality assessment as well as studying the effects of a polyphenol‐rich diet on human health. The assay is easy to use both in industry laboratories as well as in research and development.

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“…A solution of compound 3 (10 mg) in 5% ethanolic H 2 SO 4 was refluxed and resulted in kaempferol on cooling [16]. The residue was partitioned between ethyl acetate and water to obtain D-glucose and p-coumaric acid, respectively, as hydrolysis products.…”

Section: Extraction and Isolation Proceduresmentioning

confidence: 99%

Antioxidant and α-glucosidase inhibitor activities of natural compounds isolated from Quercus gilva Blume leaves

Indrianingsih

Tachibana

Dewi

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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Objective: To isolate and investigate antioxidant and a-glucosidase inhibitor compounds in the leaves of Quercus gilva Blume (Q. gilva). Methods: Dry leaves of Q. gilva were extracted with methanol and the methanolic extract was further separated by silica gel column chromatography using several solvents with increasing polarity. The antioxidant activities of the isolated compounds were evaluated using various in vitro assays: 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, hydrogen peroxide radical scavenging activity, b-carotene bleaching assay, and reducing power assay. The a-glucosidase inhibitory assay was conducted against aglucosidase from Saccharomyces cerevisiae. Results: Three compounds were isolated and their structures were identified as catechin (1), epicatechin (2), and tiliroside (3) using an instrumental analysis. Compound 2 had higher antioxidant activity with inhibitory concentrations (IC 50 ) of (22.55 ± 2.23) mmol/L than that of quercetin, which was used as the standard, with an IC 50 of (28.08 ± 2.39) mmol/L, followed by compound 1 with IC 50 of (40.86 ± 3.45) mmol/L. On the other hand, compound 3 had the lowest antioxidant activity with an IC 50 of (160.24 ± 8.15) mmol/L. However, compound 3 had the highest a-glucosidase inhibitory activity with an IC 50 of (28.36 ± 0.11) mmol/L, followed by compounds 1 and 2 with (168.60 ± 5.15) and (920.60 ± 10.10) mmol/L, respectively. Conclusions: The results obtained for the antioxidant activities and a-glucosidase inhibitory activities in a methanolic extract from the leaves of Q. gilva confirmed the potential of this plant as a source of natural antioxidants and antidiabetic medicine.

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Flavonol glycosides found in hydroethanolic extracts from Tilia cordata, a species utilized as anxiolytics

Cited by 42 publications

References 30 publications

Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.

Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.

Determination of Total Phenolic Compounds in Common Beverages Using CdTe Quantum Dots

Antioxidant and α-glucosidase inhibitor activities of natural compounds isolated from Quercus gilva Blume leaves

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