Secretory Otitis Media

The Pathogenesis of Chronic Secretory Otitis Media

“…Stenosis of the orifice due to epithelial proliferation or transformation of simple to stratified epithelium in the orifice. 3. Inadequate transport of the mucus away from the orifice, leading to obstruction of the orifice from the outside.…”

Tympano-Mastoid Cholesterol Granuloma: Case Report and Review of the Literature

“…14 Cochlear invasion is rare and, in the literature, only 2 cases are reported. 12,15,16 Imaging Today, imaging used to diagnose cholesterol granuloma consists of CT and MRI. 2,17 Computed Tomography (CT) associated with contrast material is a poor specific test for TMCG, unable to make a differential diagnosis.…”

“…Histological evidence of cholesterol granuloma is characterised by foreign body, giant cell reaction to cholesterol crystals and haemosiderin derived from the ruptured of the erythrocytes. 7,12 Iannella et al, in 2017, investigated the immunohistochemical expression of VEGF and CD34 in a group of patients surgically treated for CGs. They demonstrated that, if conducted, immunohistochemistry shows that endothelial cells present an increased expression of angiogenetic growth factor receptors (VEGF and CD34).…”

Review of Chronic Secretory Otitis and Allergy

“…With inflammation or possibly allergy, or both, the middle ear mucosa changes, becoming columnar ciliated" by extension from the tympanic orifice," or as more conirnonly thought, by i n e t a p l a~i a .~~ 21 Some evidence also suggests that squamous cells are noted. Paparella47 states, however, that the squamous epithelium noted lacked intercellular bridges and thus applied the term "squamoid" to this finding.…”