The Pathogenesis of Chronic Secretory Otitis Media

Tos, Mirko; Bak-Pedersen, K.

doi:10.1001/archotol.1972.00770080801004

Cited by 59 publications

(12 citation statements)

References 12 publications

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“…Otitis media with effusion (OME) is a disease in which secreted fluid accumulates in the middle ear cavity and is a major cause of hearing loss in children [7,8]. Among the possible causes of otitis media are Eustachian tube dysfunction, bacterial or viral infection, family history, and allergies, with inflammatory reactions induced by pathogen stimulation thought to be important [9].…”

Section: Discussionmentioning

confidence: 99%

TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion

Kim

Park

Shim

et al. 2010

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion

Kim

Park

Shim

et al. 2010

International Journal of Pediatric Otorhinolaryngology

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“…Sade et al (1975) demonstrated that the main difference between viscous and serous secretion was due predominantly to differences in the amount o f glycoproteins and the extent to which they were cross-linked by disulphide bonds. The histological phase {Tos and Bak-Pedersen, 1972) o f the disease is also not consistently correlated with the appearance of the effusion. Considering these results, the gross nature o f the MEE can hardly be expected to correlate with the prognosis.…”

Section: Type O F M Eementioning

confidence: 89%

Tympanometry in Three-Year-Old Children

Fiellau-Nikolajsen¹,

Lous²

1979

ORL

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The operative findings in a homogeneous, preoperatively followed population of 46 3- to 4-year-old children with middle ear effusion treated by adenotomy and paracentesis were correlated with the results of pre- and postoperative tympanometry. Factors of prognostic value were only the immediate type of tympanogram and the quantity of the middle ear effusion, not its viscosity. The combination of the determinative factors divided the material into four groups showing a different course through a 6-month postoperative follow-up. A flat tympanogram and impacted fluid spelt the poorest prognosis, with about 60% recurrences. The influence of the results upon a differentiated treatment of secretory otitis media in the younger age groups is outlined.

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“…For example, the development and pathophysiology of OME may be due to inflammatory responses to bacterial infection in the Eustachian-tubes, resulting in the infiltration of inflammatory cells and various inflammatory mediators [3]. The role of allergy in otitis media, however, is unclear, since 10-80% of these patients have been reported to have allergies [4].…”

Section: Introductionmentioning

confidence: 99%