Expression of GATA3, T-bet, IL-4, and IFN-γ mRNA in the effusion of OME patients

Shim, Hyun Joon; Park, Dong Choon; Lee, Young Chan; Eun, Young Gyu

doi:10.1016/j.ijporl.2009.04.024

Cited by 1 publication

(1 citation statement)

References 32 publications

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“…The role of allergy and the Th1/Th2 balance by expression of GATA3, T‐bet, IL‐4, and IFN‐γ mRNA in OME patients was investigated in fluid collected from 46 OME patients having ventilating tubes inserted 255 . The study showed that although levels of GATA3 and T‐bet mRNA in effusion fluid correlated positively with the levels of IL‐4 and IFN‐γ mRNA, respectively, there was no difference between the allergy and nonallergy groups, thus questioning that OME with allergy is related to a Th2‐driven immune response.…”

Section: Discussionmentioning

confidence: 99%

Panel 5: Microbiology and Immunology Panel

Murphy

Chonmaitree

Barenkamp

et al. 2013

Otolaryngol.--head neck surg.

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Objective The objective is to perform a comprehensive review of the literature from January 2007 through June 2011 on the virology, bacteriology, and immunology related to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Three subpanels with co-chairs comprising experts in the virology, bacteriology, and immunology of otitis media were formed. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a second draft was created. The entire panel met at the 10th International Symposium on Recent Advances in Otitis Media in June 2011 and discussed the review and refined the content further. A final draft was created, circulated, and approved by the panel. Conclusion Excellent progress has been made in the past 4 years in advancing an understanding of the microbiology and immunology of otitis media. Advances include laboratory-based basic studies, cell-based assays, work in animal models, and clinical studies. Implications for Practice The advances of the past 4 years formed the basis of a series of short-term and long-term research goals in an effort to guide the field. Accomplishing these goals will provide opportunities for the development of novel interventions, including new ways to better treat and prevent otitis media.

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Section: Discussionmentioning

confidence: 99%