Secondary Metabolites from the Marine Algal-Derived Endophytic Fungi: Chemical Diversity and Biological Activity

Zhang, Peng; Li, Xin; Wang, Bin‐Gui

doi:10.1055/s-0042-103496

Cited by 46 publications

(34 citation statements)

References 96 publications

(157 reference statements)

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“…Cyclic peptides (also called cyclopeptides) are cyclic compounds formed mainly by proteinogenic or non-proteinogenic amino acids joined together by amide bonds (or peptide bonds). Cyclic peptides have been isolated from plants [ 1 ], fungi [ 2 ], bacteria (including actinomycetes) [ 3 ], sponges [ 4 ], algae [ 5 , 6 ], and mammals [ 7 ]. Among these organisms, fungi are well-known producers of a diversity of cyclic peptides with interesting structures and biological activities [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Wang

Lin

et al. 2017

Molecules

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Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds in the core ring) reported until August 2017. About 293 cyclic peptides belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, undeca-, dodeca-, tetradeca-, and octadecapeptides as well as cyclic peptides containing ether bonds in the core ring have been isolated from fungi. They were mainly isolated from the genera Aspergillus, Penicillium, Fusarium, Acremonium and Amanita. Some of them were screened to have antimicrobial, antiviral, cytotoxic, phytotoxic, insecticidal, nematicidal, immunosuppressive and enzyme-inhibitory activities to show their potential applications. Some fungal cyclic peptides such as the echinocandins, pneumocandins and cyclosporin A have been developed as pharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Wang

Lin

et al. 2017

Molecules

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“…reportedly being a source of novel bioactive agents [15][16][17] including potent antiviral compounds [18]. Interestingly, compounds with activity against RSV have been reported in lichen [19] and marine derived fungi [20].…”

Section: Discussionmentioning

confidence: 99%

Anti-Respiratory Syncytial Virus Compounds from Two Endophytic Fungi Isolated from Nigerian Medicinal Plants

et al. 2016

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Respiratory syncytial virus (RSV) is known to cause severe respiratory infections particularly in infants younger than 2 years of age. The only approved drug, ribavirin, is expensive and is not likely to improve therapeutic outcome, thereby necessitating the search for safer and more potent alternatives from natural sources such as endophytic fungi. The present study aimed to investigate the anti-RSV activity of compounds from endophytic fungi. Two endophytic fungi and were isolated from the fresh leaves of the host Nigerian plants and respectively. After fermentation in solid rice media, afforded 4 known compounds 4-hydroxybenzoic acid (), vanillic acid (), ferulic acid () and N-acetyltryptamine ( while afforded 3 known compounds chloroisosulochrin (), ficipyrone A () and pestheic acid (). The compounds were investigated for their anti-RSV activity using the HEP-2 cell lines and ribavirin as the standard drug. Compound was found to show the strongest inhibition of the RSV with IC of 4.22±1.03 µM (ribavirin 4.91±1.85 µM). Other compounds showed moderate inhibition of the virus (IC ranging from 45.00±0.98 to 259.23±2.36 µM). The results of the present study have shown that chloroisosulochrin (), isolated from an endophytic fungus possesses strong activity against RSV.

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“…Endophytic and epiphytic fungi have proven to be prolific sources of bioactive natural products with unique structures and potent pharmaceutical activity; such fungi harmoniously colonize the internal tissues of their hosts usually without causing obvious damage to the hosts [72,73]. Marine-derived fungi could be isolated from every possible marine habitat, such as marine sediments, marine invertebrates (sponges, corals, ascidians, and holothurians), and vertebrates (mainly fish), as well as marine plants (algae, driftwood, and mangrove plants) [74,75]. As shown in Table 1 [46,56,64], while the other strains were collected from marine sediments at depths above 100 m or even tideland mud [28,35,36,40,42,57,65,69,70].…”

Section: Production Environmentmentioning

confidence: 99%

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Yuan

et al. 2020

Marine Drugs

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Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived Aspergillus species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived Aspergillus species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.

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Secondary Metabolites from the Marine Algal-Derived Endophytic Fungi: Chemical Diversity and Biological Activity

Cited by 46 publications

References 96 publications

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Anti-Respiratory Syncytial Virus Compounds from Two Endophytic Fungi Isolated from Nigerian Medicinal Plants

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

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