Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

Caryolane-type sesquiterpenes from Cirsium souliei

“…A few natural caryolane sesquiterpenes were reported from Sindora sumatrana (family Leguminosae) (Heymann et al, 1994a,b), Senecio species (Asteraceae) (Bohlmann and Ziesche, 1981), Sinacalia tangutica (Asteraceae) (Zhu et al, 2008), Cyperus longus (Cyperaceae) (Xu et al, 2004), Magnolia obovata (Magnoliaceae) (Matsuda et al, 2001), and Neolitsea hiiranensis (Lauraceae) (Liou et al, 2011). Most of the stereochemical orientations of the methano bridge were opposite H-2 (Bohlmann and Ziesche, 1981;Heymann et al, 1994a;Matsuda et al, 2001;Xu et al, 2004;Choudhary et al, 2006;Zhu et al, 2008;Liou et al, 2011). Only 9-oxoisocaryolane-1-ol from Sindora sumatrana possessed the same orientation (Heymann et al, 1994b).…”

Chemical constituents of plants from the genus Neolitsea

“…In the course of further investigation on the chemical constituents of this plant, four novel sesquiterpenes of the furanogermacrane type 7-10 have been isolated from the stems of N. parvigemma [2]. In 2011, investigation of N. hiiranensis revealed seven new sesquiterpenoids 12-18 and 12 known sesquiterpenoids 19-30 from the leaves of this plant [3]. In 1983, Nozaki et al isolated a new sesquiterpene dilactone 31, named neoliacine, from the leaves of N. aciculata, and they further examined chemical components of the same plant and isolated the sesquiterpene acid 32 [14,15].…”

“…A phytochemical investigation of the crude chloroform extract of the Neolitsea dealbata bark revealed two common triterpenes 68, 69, which were reported for the first time from this plant [21]. Investigation of the ethyl acetate-soluble extract of the leaves of N. hiiranensis led to the isolation of hiiranterpenone 70 [3]. Chan and Hui isolated three C 32 triterpenes 71-73 by column chromatography of the light petroleum extract [23].…”

“…And the inhibitory activity against fMLP-induced superoxide production with IC 50 values of 21.86±3.97 and 25.78±4.77 mm, respectively [3]. Six furanogermacranes 1, 5-7, 10, 11 were tested for anti-inflammatory activities.…”

“…The plants of genus Neolitsea have been found to be rich in sesquiterpenes, triterpenes, alkaloids, and steroids [1,2]. The occurrence of a small number of flavonoids, benzenoids, monoterpenes, and benzoquinone has also been reported [3]. Constituents of the Neolitsea genus (Lauraceae) have been reported to possess diverse bioactivities, such as antioxidant, antibacterial, antiinflammatory activities, and cytotoxicity [3].…”