Secondary Metabolites From Endophytic Fungi and Their Biological Activities

Vasundhara, M.; Reddy, M. Sudhakara; Kumar, Anil

doi:10.1016/b978-0-444-63504-4.00018-9

Cited by 31 publications

(22 citation statements)

References 134 publications

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“…One advantage of culture-based method is to preserve the living fungal cultures which are valuable for further studies. Fungal endophytes produce secondary metabolites, which might be useful for biomedical application [ 51 ], and living cultures from ecological surveys are excellent sources for further studies. Moreover, the cryptic biodiversity of fungi has not been fully studied yet, and the preserved cultures from the community studies provide the chance for discovering new taxa.…”

Section: Discussionmentioning

confidence: 99%

Effect of Host, Environment and Fungal Growth on Fungal Leaf Endophyte Communities in Taiwan

Huang

2020

JoF

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Fungal endophytes inhabit plant tissues without causing disease symptoms. They are highly diverse and distributed globally in all plants that have been investigated. Host, geographic, and environmental effects on endophyte communities have been reported in several studies, but the direct effect of fungal growth rate on endophyte composition has not been tested. To understand the relationship between foliar endophyte composition and fungal growth and to examine the effect of host, elevation, and climatic factors on the foliar endophyte communities, this study examined the foliar endophyte communities of representative gymnosperms and Rhododendron spp. across different elevations of Hehuanshan and Taipingshan forests in Taiwan. The isolation frequency and diversity of foliar endophytes were higher at low elevations than at high elevations. The foliar endophyte community structure differed as a function of host family and forest vegetation type. Elevation, mean annual temperature, and precipitation were significantly correlated with the community structure. Fungal growth rate was correlated with the endophyte abundance, which indicates that fast-growing fungi might have a competitive advantage when coexisting with other fungi in a plant host.

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Section: Discussionmentioning

confidence: 99%

Effect of Host, Environment and Fungal Growth on Fungal Leaf Endophyte Communities in Taiwan

Huang

2020

JoF

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“…showed a potential antifungal activity, and five compounds: 2-hexyl-3-methylbutanodioic acid (1), cytochalasin D (2), 7-dechlorogriseofulvin (3), cytochalasin B (4) and griseofulvin (5) were obtained ( Figure 3) [97]. The continuing search for endophytes associated on A. macrophylla led to five new eremophilane sesquiterpenes: xylarenones C-G (14)(15)(16)(17)(18) isolated from solid cultures of Camarops sp. (Boliniaceae) [100,101].…”

Section: J Fungi 2020 6 X For Peer Review 3 Of 31mentioning

confidence: 99%

“…-dihydroxybut-3-enyl)-5H-furan-2-one (21) and (2E,4R)-2,4dimethylnon-2-enoic acid (22); seven phenolic derivatives: p-hydroxyphenyllactic acid (23), phenyllactic acid (24), p-hydroxybenzoic acid (25), p-hydroxybenzaldehyde (26), n-butyl-3,4dihydroxybenzoate (27), n-hexyl-3,4-dihydroxybenzoate (28) and n-octyl-3,4-dihydroxybenzoate (29); and the known compound (2E,4S)-2,4-dimethyloct-2-enoic acid (30) ( Figure 5) [102]. The continuing search for endophytes associated on A. macrophylla led to five new eremophilane sesquiterpenes: xylarenones C-G (14)(15)(16)(17)(18) isolated from solid cultures of Camarops sp. (Boliniaceae) [100,101].…”

Section: J Fungi 2020 6 X For Peer Review 3 Of 31mentioning

confidence: 99%

“…The term endophyte refers to the microorganism that colonizes interior organs of plants, generally inhabiting their aerial parts such as stems and leaves, but that does not have pathogenic effects on its host [1,7,[13][14][15][16]. Endophytes are ubiquitously found in every plant species examined to date.…”

Section: Introductionmentioning

confidence: 99%

“…Endophytic fungi are known to produce a wide range of bioactive secondary metabolites, emphasizing chemical diversity, molecules originality and their biological activities [ 1 , 7 , 9 , 15 , 16 , 17 , 19 , 20 , 21 , 22 , 23 , 24 ]. Some studies suggest that up to 51% of bioactive metabolites obtained from endophytic fungi have unknown chemical structure, which highlights the huge biotechnological potential of this microbial group to the discovery of new drugs [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Natural Products from Endophytic Fungi Associated with Rubiaceae Species

Cruz

Silva

Hamerski

2020

JoF

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This review presents the chemical diversity and pharmacological properties of secondary metabolites produced by endophytic fungi associated with various genera of Rubiaceae. Several classes of natural products are described for these endophytes, although, this study highlights the importance of some metabolites, which are involved in antifungal, antibacterial, anti-protozoal activities; neurodegenerative diseases; cytotoxic activity; anti-inflammatory and antioxidant activity; and hyperglycemic control.

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Reflections on the intriguing occurrence of some recently isolated natural products as racemates and scalemic mixtures

Zask

Ellestad

2021

Chirality

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This review continues our interest in the intriguing reports of a variety of new racemic natural products (at least 11 in the past 4 years). These include the polyphenolic racemate galewone, the polycyclic prenylated acylphloroglucinol garcinielliptone; variecolortide, a combination of an anthraquinone and a isochinulin‐type alkaloid; the isoindoline alkaloid irpexine, the new hybrid phenylproanoid asarone; colletopyandione an indolydenepyradione; the enantiomerically enriched (scalemic) neolignans, gardenifolins; and meroterpenoid pabmaragramin in addition to some marine lipids. We also present a recent biomimetic synthesis of the polyketide preuisolactone A; synthesis of the polyketide spiromamakone A, which also corrected the proposed structure of another metabolite as identical to spiromamakone A; and the melicolones A and B. The continuing reports of natural racemates provoke speculation as to their role in the producing organism.

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Secondary Metabolites From Endophytic Fungi and Their Biological Activities

Cited by 31 publications

References 134 publications

Effect of Host, Environment and Fungal Growth on Fungal Leaf Endophyte Communities in Taiwan

Effect of Host, Environment and Fungal Growth on Fungal Leaf Endophyte Communities in Taiwan

Natural Products from Endophytic Fungi Associated with Rubiaceae Species

Reflections on the intriguing occurrence of some recently isolated natural products as racemates and scalemic mixtures

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