Secondary metabolites as anti-inflammatory agents

Garelnabi, Elrashied A. E.; Mohammed, Mona S.; Osman, Wadah; Osman, Zuheir; Osman, Bashier; Khalid, Hassan S.; Mohamed, Magdi A.

doi:10.31254/phyto.2014.3409

Cited by 42 publications

(18 citation statements)

References 32 publications

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“…Secondary metabolites like alkaloids, flavonoids, tannins, saponins, coumarins etc., act as the sources of anti-inflammatory agents [18]. The GC-MS analysis shows the presence of some bioactive compounds present in the extract.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Activity of Sclerotium stipitatum Berk. et. Curr. an Ethnomedicinal Fungus, in Chronic and Acute Animal Models of Inflammation

Sebastian

Anto

2021

JPRI

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Sclerotium stipitatum Berk. et. Curr., locally known as ‘nilamanga’ is a rare macro fungus, traditionally used to treat numerous diseases like arthritis, earache, jaundice etc. The present study aims to evaluate the anti-inflammatory activity of ethanol extract of S. stipitatum and identify the bioactive compounds present in them. Phytochemical screening of extracts obtained using different solvents like petroleum ether, chloroform, ethanol and water were done. The best extract was chosen for the acute carrageenan-induced and chronic formalin-induced anti-inflammatory studies. Diclofenac was used as the standard drug. Ethanol extract showed significant inhibition of inflammation induced by carrageenan and formalin-induced paw edema models compared to the control. GC-MS analysis shows certain bioactive compounds. The significant inhibitory effect on paw edema proves that S. stipitatum possesses remarkable anti-inflammatory activity, and isolation and identification of bioactive compounds can be used for new drug formulations.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Activity of Sclerotium stipitatum Berk. et. Curr. an Ethnomedicinal Fungus, in Chronic and Acute Animal Models of Inflammation

Sebastian

Anto

2021

JPRI

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“…Flavonoids have an antiinflammatory response via many routes and block molecules such as COX, INS, cytokines, and matrix metalloproteinases. Some flavonoids such as quercetin blocked the cyclooxygenase and lipooxygenase pathways when concentrations were relatively high, whereas at lower concentrations the lipooxygenase pathway was the main target of antiinflammatory activity [20]. This is supported by the opinion of Nijvelt, flavonoids also have an anti-inflammatory response through many mechanisms, namely inhibiting cyclooxygenase (COX) and lipooxygenase activity, inhibiting leukocyte accumulation, inhibiting neutrophil degranulation, and inhibiting histamine [21].…”

Section: Anti-inflammatory Activities Of Miang Bean Leavesmentioning

confidence: 94%

Anti-Inflammatory Effects of Miang Bean Leaves (Mucuna pruriens)

Fadilaturahmah

Syukri

Afriani

et al. 2022

J. Trop. Pharm. Chem.

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Inflammation is a serious health problem that needs treatment. The use of steroids and non-steroidal anti-inflammatory drugs (NSAIDs) can actually relieve inflammatory reactions well, but their long-term use can have many side effects and are uneconomical. Therefore, the use of natural ingredients that are effective and economical is needed. One of the plants that are considered anti-inflammatory is the leaves of miang beans (Mucuna pruriens). The purpose of compiling this narrative review is to analyze the phytochemical content of miang beans leaves and its mechanisms for inflammatory reactions. The narrative study of this preparation was carried out using the literature study method from August to September 2020. The phytochemical content of miang bean leaves are alkaloids, flavonoids, saponins, cyanogenic glycosides, and tannins. Phytochemicals that have a direct anti-inflammatory effect are alkaloids, flavonoids, saponins, and tannins. Alkaloids are antibacterial. If there are bacteria that cause inflammation, the alkaloids will damage the bacterial peptidoglycan cell walls, thus causing bacterial cell death and preventable inflammatory reactions. Flavonoids have anti-inflammatory effects by inhibiting macrophages from producing NO (nitric oxide) and inhibiting the cyclooxygenase pathway. Saponins affect the inflammatory reaction by inhibiting the lipoxygenase pathway and inhibiting the release of inflammatory mediators. Meanwhile, tannins affect the inflammatory reaction by inhibiting macrophages from producing ROS (Reactive Oxygen Species). Potential which is fatal because it can turn into cyanide acid. However, the content of these cyanogenic glycosides can be minimized by drying at low temperatures. So, mung bean leaves are effective as anti-inflammatory drugs because the alkaloids, flavonoids, saponins, and tannins they contain are anti-inflammatory.

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“…This denaturation process can be inhibited by secondary metabolites such as flavonoids. The ethanol extract and ethyl acetate fraction have secondary metabolites that have the potential as anti-inflammatory, namely flavonoids, tannins, saponins, alkaloids, steroids and terpenoids (Tiyagi, et al, 2018;Souto, et al, 2011;Mohammed et al, 2014).…”

Section: Anti-inflammatory Activity Testmentioning

confidence: 99%

“…Tannins have anti-inflammatory effects including radical scavenging and inhibition of inflammatory mediators, such as several cytokines and COX-2. Saponins have a mechanism in inhibiting glucocorticoid degradation, inhibition of enzymatic formation and the release of inflammatory mediators (Mohammed, et al, 2014).…”

mentioning

confidence: 99%

ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION OF KEBIUL (Caesalpinia bonduc L.) SEED COAT AGAINST INHIBITION OF PROTEIN DENATURATION

Fitriyani

Fatahillah²

2022

JKR

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Inflammation is a normal protective reaction against tissue damage caused by physical injury, harmful chemicals, and protein denaturation. Protein denaturation is a process in which proteins lose their tertiary structure and secondary structure due to foreign substances, external compounds, such as strong acids, strong bases, organic salts, organic solvents, and heating. The purpose of this study was to determine the anti-inflammatory activity of ethanol extract and ethyl acetate fraction of the seed coat of Kebiul (Caesalpinia bonduc L.) by calculating the IC50 value of protein denaturation in the sample. The results of the phytochemical test of the ethanol extract of Kebiul seeds contained flavonoids, alkaloids, terpenoids, steroids, saponins, and tannins, while the ethyl acetate fraction only contained tannins and alkaloids. The results of the anti-inflammatory test showed that the highest percent inhibition value of sodium diclofenac, ethanol extract, and ethyl acetate fraction, respectively, at a concentration of 20 ppm was 84.8%; 84.1%; and 50%. The IC50 values of sodium diclofenac, ethanol extract, and ethyl acetate fraction were 5.4 μg/mL; 9.9 μg/mL; and 13.3 μg/mL, respectively. The three samples had percent inhibition values exceeding 20% which indicated that all three can be used as an anti-inflammatory. Keywords: anti-inflammatory, protein denaturation, Caesalpinia bonduc L.

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Secondary metabolites as anti-inflammatory agents

Cited by 42 publications

References 32 publications

Anti-inflammatory Activity of Sclerotium stipitatum Berk. et. Curr. an Ethnomedicinal Fungus, in Chronic and Acute Animal Models of Inflammation

Anti-inflammatory Activity of Sclerotium stipitatum Berk. et. Curr. an Ethnomedicinal Fungus, in Chronic and Acute Animal Models of Inflammation

Anti-Inflammatory Effects of Miang Bean Leaves (Mucuna pruriens)

ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION OF KEBIUL (Caesalpinia bonduc L.) SEED COAT AGAINST INHIBITION OF PROTEIN DENATURATION

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