Secondary Hyperparathyroidism and Hypovitaminosis D in African-Americans with Decompensated Heart Failure

LaGuardia, S. P.; Dockery, Brian K.; Bhattacharya, Syamal K.; Nelson, M. D.; Carbone, Laura D; Weber, Karl T.

doi:10.1097/00000441-200609000-00003

Cited by 65 publications

(58 citation statements)

References 56 publications

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“…Two further studies among African Americans also showed a high prevalence of vitamin D deficiency in patients with heart failure [84,85]. Interestingly, not all heart-failure patients with vitamin D deficiency show elevations in PTH levels but those with secondary hyperparathyroidism have more severe forms of heart failure [83][84][85]. In a cohort of over 3000 patients referred for coronary angiography 25(OH)D as well as 1,25(OH)D were inversely correlated with left ventricular dysfunction, New York Heart Association functional class and N-terminal pro-B type natriuretic peptide (NT-pro-BNP) [86].…”

Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 89%

“…In a study among 102 African Americans, vitamin D deficiency was observed in 84-96% of heart-failure patients, whereas only one-third of the healthy controls was vitamin D deficient [83]. Two further studies among African Americans also showed a high prevalence of vitamin D deficiency in patients with heart failure [84,85]. Interestingly, not all heart-failure patients with vitamin D deficiency show elevations in PTH levels but those with secondary hyperparathyroidism have more severe forms of heart failure [83][84][85].…”

Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 97%

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Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

134

142

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Vitamin D deficiency is common among patients with myocardial diseases because sun-induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient. Knockout mice for the vitamin D receptor develop myocardial hypertrophy and dysfunction. It has also been shown that children with rickets who suffered from severe heart failure could be successfully treated with supplementation of vitamin D plus calcium. In adults, almost all patients with heart failure exhibit reduced 25-hydroxyvitamin D levels, which are used to classify the vitamin D status. In prospective studies, vitamin D deficiency was an independent risk factor for mortality, deaths due to heart failure and sudden cardiac death. Several vitamin D effects on the electrophysiology, contractility, and structure of the heart suggest that vitamin D deficiency might be a causal factor for myocardial diseases. Data from interventional trials, however, are rare and urgently needed to elucidate whether vitamin D supplementation is useful for the treatment of myocardial diseases. In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases.

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Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 89%

Section: Vitamin D Deficiency and Heart Failure In Adultsmentioning

confidence: 97%

Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

134

142

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“…Through increased urinary excretion of calcium and magnesium, enhanced by loop diuretic use [28,29], elevated aldosterone levels drive PTH release. This response is exacerbated in people with 25[OH]D deficiency [30,31]. The consequences of 25[OH]D deficiency [32] and elevated PTH levels [33][34][35][36] are calcium loading, with cardiomyocyte and skeletal muscle contractile dysfunction, cellular hypertrophy, oxidative stress, immune activation, endothelial dysfunction (including enhanced endothelin-1 release) [30,34,[37][38][39][40][41].…”

Section: Why Might Vitamin D Be Important In Chronic Heart Failure?mentioning

confidence: 99%

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure

et al. 2018

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“…Odnos izmeu razine vitamina D te uËestalost i stupanj zatajivanja srca je istraaeena u nekoliko studija [60][61][62][63][64][65][66] . Istraaeivanje na Afroamerikancima koji su bili podijeljeni u tri skupine srËanog zatajivanja nije dokazalo povezanost izmeu koncentracije kalcidiola i stupnja srËanog zatajivanja.…”

Section: Vitamin D I Zatajivanje Srcaunclassified

“…The relation between vitamin D level and incidence and degree of heart failure has been explored in several studies [60][61][62][63][64][65][66] . The trial on African-Americans who were divided into three groups of heart failure has not proven the correlation between the concentration of calcidiol and a degree of heart failure.…”

Section: Vitamin D and Heart Failurementioning

confidence: 99%

Vitamin D and cardiovascular diseases

Josipović¹,

Pavlović²

2014

Cardiol Croat.

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Cardiologia CROATICA UvodKlasiËna uloga vitamina D je poveÊanje apsorpcije kalcija u crijevima . Istraaeivanja su pokazala da manjak vitamina D uzrokuje poveÊanje rizika od razvoja srËanoaeilnih bolesti (SAEB). NaËin na koji vitamin D πtiti pojedinca od SAEB nije do kraja istraaeen. Postoje mnoge teorije, ukljuËujuÊi negativnu regulaciju renina i time sniaeavanje arterijskog tlaka (AT), sniaeavanje razine paratiroidnog hormona (PTH) i poboljπanje kontrole glikemije (Tablica 1). Fiziologija vitamina DVitamin D se pojavljuje u dva oblika: vitamin D2 (ergokalciferol) i vitamin D3 (kolekalciferol). Vitamin D2 koji se nalazi u biljkama i kvascu, proizvod je djelovanja ultraljubiËastih zraka na ergosterol dok se vitamin D3 nalazi u masnoj ribi i ulju dobivenom iz bakalarove jetre te maslacu. Vrlo su male koliËine u mesu, kravljem i ljudskom mlijeku. Vitamin D iz hrane apsorbira se u tankom crijevu ovisno o apsorpciji lipida i hilomikronima prelazi u limfu i u krv te u jetru. OpÊenito se apsorbira 50% vitamina D uneπenog hranom (Slika 1).

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Secondary Hyperparathyroidism and Hypovitaminosis D in African-Americans with Decompensated Heart Failure

Cited by 65 publications

References 56 publications

Vitamin D deficiency and myocardial diseases

Vitamin D deficiency and myocardial diseases

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure

Vitamin D and cardiovascular diseases

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