Secondary extension of Hodgkin's disease to the skin with positive staining for EBV‐encoded latent membrane protein

Abstract

Cutaneous involvement with Hodgkin's disease in HIV‐positive patients is infrequent. Although the large majority of these cases are pathogenetically linked to Epstein‐Barr virus, demonstration of viral oncogenes in skin involvement of Hodgkin's disease has rarely been performed. We report an HIV‐positive male with aggressive Hodgkin's disease and specific cutaneous involvement. The presence of Epstein‐Barr virus in cutaneous and lymph node samples could be demonstrated by a positive reaction to the Epstein‐Barr virus latent‐encoded membrane protein.