Acral erythema is a well-known side-effect of chemotherapy treatment but it is not common in patients undergoing bone marrow transplant. We report a post-transplant patient with clinical and histological acute graft-versus-host disease (GVHD) who concurrently developed acral erythema presenting as painful, well-defined and self-limiting palmar erythema with pustules. A skin biopsy from the palm showed abnormal keratinocyte maturation and eccrine squamous syringometaplasia. This case illustrates the difficulties in establishing the differential diagnosis of cutaneous eruptions in patients undergoing bone marrow transplant.
Cutaneous involvement with Hodgkin's disease in HIV‐positive patients is infrequent. Although the large majority of these cases are pathogenetically linked to Epstein‐Barr virus, demonstration of viral oncogenes in skin involvement of Hodgkin's disease has rarely been performed. We report an HIV‐positive male with aggressive Hodgkin's disease and specific cutaneous involvement. The presence of Epstein‐Barr virus in cutaneous and lymph node samples could be demonstrated by a positive reaction to the Epstein‐Barr virus latent‐encoded membrane protein.
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