Second-trimester sex hormone-binding globulin and subsequent development of pre-eclampsia

Yu, CKH; Papageorghiou, A.T.; Bindra, Renu; Spencer, Kevin; Nicolaides, Kypros H.

doi:10.1080/jmf.16.3.158.162

Cited by 16 publications

(16 citation statements)

References 22 publications

(11 reference statements)

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“…Although body mass index and maternal lipid profile of the participants are missing in our study, maternal weight (prepregnancy, at serum sampling and at birth) was not correlated with SHBG levels. In contrast, in a cross‐sectional study, second‐trimester SHBG was correlated with body mass index 21 . Elevated levels of triglycerides in pregnancy might explain the potential role that lipogenesis may play in suppressing levels of SHBG and development of insulin resistance.…”

Section: Discussionmentioning

confidence: 70%

“…In our study, although women subsequently diagnosed with GDM had significantly higher systolic and diastolic blood pressures compared with normal pregnancies, no correlation was found between early gestational age SHBG levels and blood pressures. In a previous study, second trimester maternal plasma SHBG concentrations were significantly lower in women who subsequently developed pre‐eclampsia than in women with normal pregnancy outcomes 21 . On the contrary, in another study, first‐trimester maternal serum SHBG concentrations were no different from controls in women who subsequently develop pre‐eclampsia and pregnancy‐induced hypertension 29 .…”

Section: Discussionmentioning

confidence: 81%

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Sex‐hormone‐binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications

Çağlar¹,

Özdemir²,

Cengiz³

et al. 2012

J of Obstet and Gynaecol

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Aims: The aim of this study was to evaluate the predictive value of sex-hormone-binding globulin (SHBG) for the diagnosis of gestational diabetes mellitus (GDM), and to clarify the association between SHBG levels and GDM complications/medication requirements. Material and Methods: Among the participants (n = 93) who provided blood samples between 13 and 16 weeks' gestation, 30 cases subsequently developed GDM. Complications and medical interventions were noted. The best cut-off point of SHBG and diagnostic performance were calculated. Results: The mean age was 28.45 Ϯ 5.0 years. SHBG levels were lower in the GDM group (n = 30) when compared with non-GDM (n = 63) cases (<0.01). Among the GDM women, SHBG was lower in the insulin therapy group (n = 15) compared with medical nutritional therapy alone (n = 15) (P < 0.01). A good predictive accuracy of SHBG was found for GDM requiring insulin therapy (area under the curve: 0.866, 95% confidence interval: 0.773-0.959). An SHBG threshold for 97.47 nmol/L had a sensitivity of 80.0%, specificity 84.6%, positive predictive value 50.0% and negative predictive value 95.7%. The calculated odds ratio for SHBG < 97.47 nmol/L was 12.346 (95% confidence interval: 1.786-83.33). Conclusions: SHBG is valuable for screening women early in pregnancy for GDM risk; however, a standard assay for analyses and a threshold level of serum SHBG for a constant gestational week has to be determined.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 81%

Sex‐hormone‐binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications

Çağlar¹,

Özdemir²,

Cengiz³

et al. 2012

J of Obstet and Gynaecol

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“…In a previous study, we showed that, in the second trimester, low maternal plasma SHBG concentration was a predictor for the subsequent development of preeclampsia (24).…”

Section: Discussionmentioning

confidence: 99%

First Trimester Sex Hormone-Binding Globulin and Subsequent Development of Preeclampsia or Other Adverse Pregnancy Outcomes

Spencer

Rembouskos

et al. 2005

Hypertension in Pregnancy

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“…), would be closely related to the onset of stillbirths during the first trimester and of pathologies affecting the mother-child binomial. The etiopathogenesis of such conditions would involve endothelial dysfunction and/or predisposing metabolic conditions having an abnormal placentation, as that seen in PE, as a common denominator [17,18,19,20,21,22]. PE shares a series of pathophysiological findings with IR, among which are the following: endothelial dysfunction, atherosclerosis and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Pregestational Insulin Resistance as a Risk Factor of Preeclampsia

Valdés

Sepúlveda‐Martínez

Manukián

et al. 2014

Gynecol Obstet Invest

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Aim: To assess the impact that pregestational insulin resistance (PIR) has as a risk factor for preeclampsia (PE). Methods: Nested case-control study that included patients with PIR and a control group that was randomly selected from pregnancies admitted to the Fetal Medicine Unit between January 2005 and May 2011. Clinical and hemodynamic variables were analyzed by a multiple logistic regression analysis. Results: Of the 13,124 patients admitted during the study period, 119 had a diagnosis of PIR (0.9%). Patients with PIR were older and had a higher body mass index (BMI). PIR was also related to a significantly higher frequency of chronic hypertension (CrHT; 10.1 vs. 2.2%, p < 0.05) and hypothyroidism (5.0 vs. 1.6%, p < 0.05) than in the control group. Moreover, women with PIR were more likely to develop PE (8.4 vs. 4.2%, p < 0.05) and gestational diabetes mellitus (9.2 vs. 2.9%) than the control group. Multivariate analysis showed that maternal age, CrHT and altered uterine artery Doppler sonography during the first and second trimesters were good predictors of PE and that PIR was not. Conclusion: Although PIR correlates with PE, conditions related to the latter (CrHT, higher maternal age and increased BMI) may be predominant as risk factors for PE.

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Second-trimester sex hormone-binding globulin and subsequent development of pre-eclampsia

Abstract: Maternal plasma SHBG concentrations are reduced in women who subsequently develop pre-eclampsia.

Cited by 16 publications

References 22 publications

Sex‐hormone‐binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications

Sex‐hormone‐binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications

First Trimester Sex Hormone-Binding Globulin and Subsequent Development of Preeclampsia or Other Adverse Pregnancy Outcomes

Assessment of Pregestational Insulin Resistance as a Risk Factor of Preeclampsia

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