Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma

Jung, Eunok; Fiore, Marco; Gronchi, Alessandro; Grignol, Valerie; Pollock, Raphael E.; Chong, Susan S; Chopra, Shefali; Hamilton, Ann S.; Tseng, William W.

doi:10.21873/anticanres.12625

Cited by 12 publications

(3 citation statements)

References 21 publications

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“…Interestingly, this patient had a synchronous second primary cancer (e.g., gastrointestinal stromal tumor). We have previously reported that some patients with liposarcoma seem to have a propensity to develop this without a clearly A B defined hereditary cancer syndrome (15). We hypothesize that in these patients, there may be an underlying genetic abnormality or possibly a defect in systemic immune surveillance, particularly when such large liposarcoma tumors are intact.…”

Section: Pathologic Discussionmentioning

confidence: 92%

Multidisciplinary sarcoma tumor board: retroperitoneal liposarcoma

et al. 2020

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Section: Pathologic Discussionmentioning

confidence: 92%

Multidisciplinary sarcoma tumor board: retroperitoneal liposarcoma

et al. 2020

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“…Based on a case series and analysis of a national cancer database, our previous work reported that some patients may be at risk of developing concurrent liposarcoma and another primary malignancy 1. There are, in fact, case reports in the literature of concurrent liposarcoma and colorectal adenocarcinoma occurring in the same patient 6 7.…”

Section: Discussionmentioning

confidence: 99%

“…Concurrent cancers have been reported, including our previous work in patients with well-differentiated (WD)/dedifferentiated (DD) liposarcoma 1. WD/DD liposarcoma is a rare cancer of putative adipocyte origin that features characteristic amplification of 12q13-15, which includes genes such as MDM2 and CDK4 .…”

Section: Introductionmentioning

confidence: 89%

Synchronous recurrence of concurrent colon adenocarcinoma and dedifferentiated liposarcoma

et al. 2019

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A 62-year-old man presented with concurrent sigmoid colon adenocarcinoma and small bowel mesenteric dedifferentiated liposarcoma. Following surgical resection of the colon cancer, complete excision of the mesenteric sarcoma and adjuvant folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy, the patient demonstrated no radiological evidence of disease for more than 2 years. The patient then developed synchronous recurrence of both cancers: the colon cancer metastasised to the liver and a pelvic lymph node, and the liposarcoma recurred in the original location. The patient underwent additional chemotherapy with complete response of the metastatic colon cancer and stable disease for the liposarcoma. The recurrent mesenteric tumour was subsequently resected. Although concurrent cancers have been reported, this unique case of synchronous recurrence raises interesting hypotheses regarding host–tumour interaction and immune surveillance.

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Isopropyl Cresols: Synthesis and Herbicidal Activity

et al. 2020

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Isopropyl cresols were prepared by a two-step process: monoterpene oxidation catalyzed by CrO 3 and terpenone isomerization catalyzed by 13X molecular sieves. 5-Isopropyl-3methylphenol and carvacrol were prepared from 3-carene, whereas thymol and 4-isopropyl-3-methylphenol were synthesized from α-pinene. The two reactions followed an identical procedure, but the reaction of 3-carene was more efficient, benefiting from the three-membered ring in the structure. 5-Isopropyl-3-methylphenol, thymol, and carvacrol were found to show higher herbicidal activity than glyphosate toward the root growth of barnyard grass. However, they exhibited slightly lower activity in preventing shoot growth. Moreover, 5isopropyl-3-methylphenol showed higher herbicidal activity than its isomers, which indicates that the relative position of substitutes is significantly associated with the herbicidal activity of isopropyl cresols.[a] J.

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Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma

Cited by 12 publications

References 21 publications

Multidisciplinary sarcoma tumor board: retroperitoneal liposarcoma

Multidisciplinary sarcoma tumor board: retroperitoneal liposarcoma

Synchronous recurrence of concurrent colon adenocarcinoma and dedifferentiated liposarcoma

Isopropyl Cresols: Synthesis and Herbicidal Activity

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