Multidisciplinary sarcoma tumor board: retroperitoneal liposarcoma

Tseng, William W.; Patel, Dakshesh B.; Miao, Changxing; Ching, Alisa; Yang, Shi; Feng, Yuanchun; Matcuk, George R.; Lara, Kristi; Hu, James; Ragab, Omar; Ho, Jennifer; Rao, Xiaosong; Hanif, Shahbaz; Luo, Cheng-Hua

doi:10.21037/cco.2020.02.08

Cited by 5 publications

(8 citation statements)

References 30 publications

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“…There are multiple subtypes of retroperitoneal liposarcomas with a diverse genomic variation, and they are usually classified into well-differentiated, dedifferentiated, pleomorphic, and myxoid types [ 3 ]. The dedifferentiated component is usually more belligerent and can metastasize to secondary locations, thus, assessment of extension and the presence of secondary lesions is essential [ 1 ]. Well-differentiated and dedifferentiated liposarcomas consist 40% of the retroperitoneal sarcomas in adults aged over 55 years.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis is usually done by enhanced CT of the abdomen and pelvis [ 1 ]. The low attenuation fat content of liposarcomas is usually distinctive.…”

Section: Discussionmentioning

confidence: 99%

“…Well-differentiated liposarcomas are found to be a lobulated or round mass of macroscopic fatty components and thin septations. In contrast in dedifferentiated liposarcomas, variable enhanced densities are found within nodular formations associated with thicker septations and calcifications [ 1 ]. The latter show amplification of genes such as MDM2 and CDK4 confined to the chromosome region 12q13-15 [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus multiorgan resection is sometimes required [ 4 ]. Multiple subtypes may be found together with a hasty transition between them [ 1 ], but this should not be confused with multifocality which is considered a bad prognosis [ 4 ]. Resection Is contraindicated when there’s metastasis, involvement of trunk vessel, or extensive spinal cord or bone involvement [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Enhanced CT scanning of the abdomen and pelvis is essential for diagnosis, which can be confirmed by performing a transcutaneous core needle biopsy. Surgery remains the standard practice in treating non-metastatic liposarcomas [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Recurrent giant retroperitoneal liposarcoma with 10 years follow up. Case report and review of literature

El-Helou

Alimoradi

Sabra

et al. 2020

International Journal of Surgery Case Reports

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Highlights Liposarcomas are a malignant transformation of fat tissue, found in two major subtypes according to their differentiation. Enhanced CT is essential for diagnosis and confirmed by percutaneous large core needle guided biopsies. Surgery remains the standard practice in treating non-metastatic liposarcomas. No clear definition for giant liposarcoma, Only 52 cases reported between 1998 and July 2020. Our patient has the longest reported follow up in the literature of 10 years, with 3 operations and 3 recurrences.

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Section: Discussionmentioning

confidence: 99%

“…The diagnosis is usually done by enhanced CT of the abdomen and pelvis [ 1 ]. The low attenuation fat content of liposarcomas is usually distinctive.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recurrent giant retroperitoneal liposarcoma with 10 years follow up. Case report and review of literature

El-Helou

Alimoradi

Sabra

et al. 2020

International Journal of Surgery Case Reports

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Synchronous retroperitoneal liposarcoma and gastric adenocarcinoma: A rare case report

Essetti,

Imrani,

Faraj

et al. 2024

Radiology Case Reports

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A better overall survival (OS) for total (ipsilateral) retroperitoneal lipectomy than standard complete resection in patients with retroperitoneal liposarcoma: a comparative multi-institutional study

Miao¹,

Zhang²,

Tseng³

et al. 2022

Ann Transl Med

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Background: Complete resection (CR) serves as the standard of surgical treatment for retroperitoneal liposarcoma (RPLS). Unfortunately, even at referral centers, recurrence rates are high, and CR may not address multifocal diseases, which are a common phenomenon in RPLS. We sought to retrospectively compare the clinical outcomes of RPLS patients treated with total (ipsilateral) retroperitoneal lipectomy (TRL) and CR. Because TRL remove potentially multifocal tumors in the fat, patients may have a better prognosis than CR.Methods: Patients with primary/first-recurrent RPLS who had been treated at 5 referral centers were recruited from December 2014 to June 2018. Multivariable Cox regression analyses were conducted to determine the effects of demographic, operative, and clinicopathological variables on the following primary endpoints: local recurrence (LR), local recurrence-free survival (LRFS), and overall survival (OS).Results: A total of 134 patients were enrolled in this retrospective study, 53 of whom underwent TRL, and 81 of whom underwent CR. The 2 groups were comparable in terms of age, gender, presentation (primary vs. first-recurrent RPLS), number of tumors (unifocal vs. multifocal) at presentation, and Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grade. The TRL group had higher levels of preoperative hemoglobin (Hb) (13 vs. 12.5 g/dL; P=0.008) and a lower amount of intraoperative blood loss (400 vs. 500 mL; P=0.034), but there were no significant differences in the length of hospital stay (23 vs. 22 d; P=0.47) or complications (32 vs. 30; P=0.82) between the 2 groups. In a subset of patients with multifocal tumors at initial presentation, OS was more prolonged in those treated with TRL than those treated with CR (P=0.0272). Based on the multivariable analysis, primary liposarcoma and a low FNCLCC grade were associated with decreased LR and improved OS.Conclusions: TRL is a safe procedure that positively affects the OS of patients with multifocal RPLS. This novel strategy deserves further investigation in prospective studies.

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Multidisciplinary sarcoma tumor board: retroperitoneal liposarcoma

Cited by 5 publications

References 30 publications

Recurrent giant retroperitoneal liposarcoma with 10 years follow up. Case report and review of literature

Recurrent giant retroperitoneal liposarcoma with 10 years follow up. Case report and review of literature

Synchronous retroperitoneal liposarcoma and gastric adenocarcinoma: A rare case report

A better overall survival (OS) for total (ipsilateral) retroperitoneal lipectomy than standard complete resection in patients with retroperitoneal liposarcoma: a comparative multi-institutional study

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