2012
DOI: 10.1177/070674371205701203
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Second-Generation Antipsychotics for the Treatment of Disruptive Behaviour Disorders in Children: A Systematic Review

Abstract: Objective: The use of second-generation antipsychotics (SGAs) in youth has increased considerably. Increases are mainly attributable to treatment of disruptive behaviour disorders (DBDs). Our objective was to review the evidence regarding the efficacy of SGAs for DBDs in youth. Method:We performed a systematic review of all randomized controlled trials (RCTs) of SGAs and placebo for the treatment of DBDs in youth, focusing on efficacy data.Results: Eight RCTs in youth with DBDs were included. Five RCTs evaluat… Show more

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Cited by 37 publications
(31 citation statements)
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“…However, there are a few evidences from controlled studies that support the use of newer antipsychotics for behavioral conditions such as ADHD (7). The most atypical antipsychotics examined in children with ADHD or conduct disorder is Risperidone (8). In many studies, ADHD was associated with different diagnoses like mental retardation, oppositional defiant disorder, bipolar mood disorder and tic disorder.…”
Section: Introductionmentioning
confidence: 99%
“…However, there are a few evidences from controlled studies that support the use of newer antipsychotics for behavioral conditions such as ADHD (7). The most atypical antipsychotics examined in children with ADHD or conduct disorder is Risperidone (8). In many studies, ADHD was associated with different diagnoses like mental retardation, oppositional defiant disorder, bipolar mood disorder and tic disorder.…”
Section: Introductionmentioning
confidence: 99%
“…In case of challenging behaviours in general, prescription of neuroleptics, particularly second generation antipsychotics, has been demonstrated to be only marginally effective [98,99]. It should be stressed that such treatments are regularly accompanied by unwanted side effects especially significant weight gain and the development over time of dislipidemia and/or diabetes mellitus, subsumed under the term metabolic syndrome [100,101].…”
Section: Discussionmentioning
confidence: 99%
“…Quoique très utilisés, les antidé presseurs ne sont pas recommandés en première instance pour la dépression ou l'anxiété chez les adolescents ou les enfants, mais peuvent être utilisés dans certaines conditions (Sparks et Duncan, 2013). Au Canada, les antipsychotiques sont utilisés relativement souvent pour les troubles de comportement, bien que les données probantes au sujet de leur efficacité soient encore limitées et que les risques associés à leurs effets métaboliques importants invitent à leur préférer des interventions psychosociales reconnues (Olfson, 2012 ;Pringsheim et Gorman, 2012). Les psychostimulants sont reconnus efficaces dans le traitement du TDAH (Brault, 2012 ;Pliszka, Carlson et Swanson, 1999), bien qu'un traitement multimodal soit recommandé parce qu'il donne des résultats supérieurs (Molina et al, 2009).…”
Section: Quand Et Comment Intervenir ?unclassified