Seborrhoeic dermatitis and<i>Pityrosporum</i>(<i>Malassezia</i>) folliculitis: characterization of inflammatory cells and mediators in the skin by immunohistochemistry

Faergemann, Jan; Bergbrant, Ing‐Marie; Dohse, Monika; Scott, A. W.; Westgate, Gillian

doi:10.1046/j.1365-2133.2001.04082.x

Cited by 152 publications

(115 citation statements)

References 21 publications

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“…79 In a subsequent study, the same author reported a greater number of NK1+ and CD16+ cells associated with complement activation in SD lesions compared to healthy skin in the same patients or to the skin of individuals without SD, suggesting the presence of an intense, irritative, nonallergic immune response. 80 In 1988, Parry and Shape failed to find either circulating antibodies against the fungus or systemic sensitivity, leading to the conclusion that there is no change in humoral response to Malassezia spp. but rather an alteration in cellular immune response.…”

Section: Immunogeneticsmentioning

confidence: 99%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment. . Keywords: Dermatitis; Dermatitis, seborrheic; Eczema Resumo: A dermatite seborreica é uma doença eritêmato-escamativa de caráter crônico-recidivante que acomete entre 1 e 3% da população geral dos Estados Unidos. Possui dois picos de incidência -o primeiro, durante os três primeiros meses de vida, e o segundo, a partir da puberdade, atingindo seu ápice entre os 40 e 60 anos de idade. Os indivíduos HIV positivos têm maior prevalência da doença, que apresenta maior intensidade e tendência à refratariedade ao tratamento. Doenças neurológicas e outras doenças crônicas também estão associadas ao desenvolvimento da dermatite seborreica. Como mecanismo fisiopatogênico, reconhece-se que o fungo Malassezia sp., presente na pele de indivíduos suscetíveis, leve a uma irritação não-imunogênica a partir da produção de metabólitos à base de áci-dos graxos insaturados deixados na superfície cutânea. Este artigo faz uma revisão da literatura sobre dermatite seborreica, com ênfase nos aspectos imunogenéticos, formas clínicas e tratamento.

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Section: Immunogeneticsmentioning

confidence: 99%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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“…Seborrheic dermatitis is characterized by red scaly lesions located predominantly on the scalp, face, and upper trunk. There are now many studies indicating that the Malassezia yeasts play an important role in seborrheic dermatitis (6,14,36,41,42,43). Many of these are treatment studies which describe the effectiveness of antimycotics, paralleled by a reduction in number of the Malassezia yeasts, whereas recolonization leads to a recurrence of seborrheic dermatitis.…”

Section: Malasseziamentioning

confidence: 99%

“…However, studies in all of these areas have given inconsistent results, and the local reaction in the skin may give a better answer. In a recent study, the number and type of inflammatory cells and mediators from lesional and healthy skin in patients with seborrheic dermatitis were been studied (43). Staining was often more intense when Malassezia yeasts cells were present.…”

Section: Malasseziamentioning

confidence: 99%

“…Under the influence of predisposing factors, Malassezia folliculitis may be explained by an extensive growth of Malassezia in the hair follicle. The inflammation may be due both to products of the yeast and free fatty acids produced as a result of the lipase activity of the yeast (7,41,43). The diagnosis is based on a typical clinical picture of itchy papules and pustules as the predominant symptoms, direct microscopy, and the effect of antimycotic treatment (7,41).…”

Section: Malasseziamentioning

confidence: 99%

“…The increased incidence of seborrheic dermatitis in patients with immunosuppressive disorders suggests that the relationship between Malassezia and the immune system is important, but the exact mechanism involved is still unknown. Studies designed to investigate this mechanism in patients with seborrheic dermatitis fall into four areas (6,43): the humoral response to Malassezia, lymphocyte transformation response to Malassezia extract, T helper (CD4)/T suppressor (CD8) cell ratios, and cytokine responses. However, studies in all of these areas have given inconsistent results, and the local reaction in the skin may give a better answer.…”

Section: Malasseziamentioning

confidence: 99%

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