Atopic Dermatitis and Fungi

Faergemann, Jan

doi:10.1111/j.1439-0507.2002.tb04591.x

Cited by 39 publications

(47 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings suggest that several types of microorganisms on the skin surface might participate in the development of AD, with each playing a different role. Among the fungal microflora, only Malassezia on the skin and Candida albicans in the gastrointestinal tract have been studied in AD patients (1,2). In the present study, our comprehensive analysis showed that not only Malassezia but also Cryptococcus species colonize the skin of AD patients.…”

Section: Discussionmentioning

confidence: 65%

The Basidiomycetous Yeasts Cryptococcus diffluens and C. liquefaciens Colonize the Skin of Patients with Atopic Dermatitis

Sugita

Saito

Ito

et al. 2003

Microbiology and Immunology

View full text Add to dashboard Cite

Our previous research showed that lipophilic yeasts, Malassezia species, colonize the skin of patients with atopic dermatitis (AD) at a high frequency. In this study, we found that two basidiomycetous yeasts, Cryptococcus diffluens and C. liquefaciens, colonize the skin significantly more frequently in AD patients than in healthy subjects. Transparent dressings were applied to the skin of 36 AD patients and 30 healthy subjects and then transferred onto Sabouraud dextrose agar. Colonies recovered from the medium were identified by DNA sequence analysis of internal transcribed spacer regions and the D1/D2 26S rRNA gene. C. diffluens and C. liquefaciens were isolated from 42% (15/36) and 33% (12/36) of AD patients and from 20% (6/30) and 20% (6/30) of healthy subjects, respectively. In addition, fungal DNA was extracted directly from the dressings and amplified in a specific nested PCR assay. C. diffluens and C. liquefaciens DNA were detected in dressings from 97% (35/36) and 86% (31/36) of the AD patients and 47% (14/30) and 37% (11/30) of the healthy subjects, respectively. These findings show that Malassezia spp. are not the only yeasts that colonize the skin of AD patients; Cryptococcus spp. also are present in a high proportion of patients. The role of these microorganisms in AD is as yet unknown, but the current findings, in combination with previous results, indicate that C. diffluens, C. liquefaciens, M. globosa, and M. restricta together colonize the skin surface of AD patients at a high frequency.

show abstract

Section: Discussionmentioning

confidence: 65%

The Basidiomycetous Yeasts Cryptococcus diffluens and C. liquefaciens Colonize the Skin of Patients with Atopic Dermatitis

Sugita

Saito

Ito

et al. 2003

Microbiology and Immunology

View full text Add to dashboard Cite

show abstract

“…aureus, Malassezia species, and Candida albicans are important triggers of cutaneous inflammation of AD (3,53,54). These microbial pathogens may induce host production of superantigen-or pathogen-specific IgE, which leads to basophil activation and histamine release (55).…”

Section: Role Of Microbial Pathogensmentioning

confidence: 99%

New insights in the pathogenesis of atopic dermatitis

Ong

2013

Pediatr Res

View full text Add to dashboard Cite

“…Malassezia has been isolated in 46%-100% of patients with atopic dermatitis and in 75%-80% of healthy adults worldwide; M. sympodialis, M. globosa, M. furfur and M. restricta were the most commonly isolated Malassezia species [10,12,13,36]. There are some reports that C. albicans has been cultured more frequently from the gastrointestinal tract in patients with AD than in that of healthy controls [37]. Increased gastrointestinal permeability in AD patients leads to enhanced transport of antigens across the gastrointestinal mucosal barrier and can favor food allergy in susceptible patients [38].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous yeast microflora in patients with atopic dermatitis

Zinkevičienė¹,

Vaiciulioniene²,

Baranauskiene³

et al. 2011

Open Medicine

View full text Add to dashboard Cite

AbstractThe skin of persons with atopic dermatitis (AD) is very susceptible to cutaneous infection, and some yeast species may also aggravate AD. The total yeast population of an AD patient’s skin and its relation with individual age and body part remains poorly characterized. The aim of this study was to clarify the differences in cutaneous yeast flora by age and body parts of AD patients.By swabbing affected body parts (hands, legs, face, neck or trunk), 241 samples were collected from patients with AD (132 children and 109 adults), and as controls, 40 samples were taken from healthy individuals (20 children, 20 adults).In all, 89 (36.9%) of samples were positive; the yeast isolated belonged to three genera: Candida (27.4%), Malassezia (6.6%), and Rhodotorula (2.9%). Cutaneous colonization with yeasts was two-fold higher in the adults than in children (P<0.0001). The distribution of the yeast species was dependent on the body part sampled: Malassezia predominated in the face, neck, and trunk regions (P=0.0047); Candida more frequently colonized hands and legs (P=0.0029).Our study showed that cutaneous yeast flora and distribution of yeast species depends significantly on the age of the AD patient and the body part affected by atopic dermatitis.

show abstract

Atopic Dermatitis and Fungi

Cited by 39 publications

References 54 publications

The Basidiomycetous Yeasts Cryptococcus diffluens and C. liquefaciens Colonize the Skin of Patients with Atopic Dermatitis

The Basidiomycetous Yeasts Cryptococcus diffluens and C. liquefaciens Colonize the Skin of Patients with Atopic Dermatitis

New insights in the pathogenesis of atopic dermatitis

Cutaneous yeast microflora in patients with atopic dermatitis

Contact Info

Product

Resources

About