Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

Abstract

The sebaceous adenocarcinoma of salivary glands is rare and may show an unfavourable outcome; therefore, its correct diagnosis may be challenging. For this reason, immunohistochemical studies, including adipophilin in particular, constitute an important diagnostic tool.

Perilipin 1 and adipophilin immunoexpression suggests the presence of lipid droplets in tooth germ, ameloblastoma, and ameloblastic carcinoma

“…2,18,19 Additionally, because of their differentiation, sebaceous adenocarcinoma cells of the major salivary glands are consistently positive for adipophilin, which is a diagnostic tool for this disease. 13,20,21 In a previous study, we observed the coexpression of FASN and cyclooxygenase-2 (COX-2) in AM and AC. Since these proteins can be coexpressed in lipid droplets, we offered a hypothesis stating that lipid droplets are present in these tumors and hence play roles in tumorigenesis, which needs to be further explored.…”

“…Finally, the authors of this previous study suggested that there is a relationship between upregulated lipogenesis and high‐grade transformation and that lipid droplets play roles in sustaining cell proliferation 2,18,19 . Additionally, because of their differentiation, sebaceous adenocarcinoma cells of the major salivary glands are consistently positive for adipophilin, which is a diagnostic tool for this disease 13,20,21 …”

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

“…Most, if not all, of the few cases reported appear to have arisen de novo and not from a pre-existing sebaceous adenoma [25,27]. A recent study of ten new cases of sebaceous adenocarcinoma also supports that they arise de novo as none of the ten reported cases had arisen from a pre-existing sebaceous adenoma [28].…”

Reccurent Sebaceous Gland Carcinoma of the Eyelid with Metastasis to the Parotid Gland and the Regional Lymph Nodes: Case Report and Review of the Literature

“…Radical or selective neck dissection should be performed, to evaluate lymph node metastasis. Adjunctive radiotherapy or chemotherapy are necessary, depending on the stage of the tumor at the time of presentation, or when the surgical margins are diffused [1,3,6,8,9,11,13,15,16].…”

“…More rare is distant metastasis to the lung, pleura, liver, brain, pericardium, lips, ethmoid sinus and skull. The overall mortality rate is 5 -10%, while in cases of metastasis the rate may go up to 25% and up to 41% in cases where the duration of symptoms lasts more than six months [1,3,8,9,[11][12][13][14].…”