2021
DOI: 10.1111/jop.13175
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Perilipin 1 and adipophilin immunoexpression suggests the presence of lipid droplets in tooth germ, ameloblastoma, and ameloblastic carcinoma

Abstract: Background Increased lipogenesis and lipid droplet accumulation are observed in diverse tumors, and these processes are associated with poor prognosis in several tumors, representing potential therapeutic targets. The presence of lipid droplets in odontogenic tissues and/or tumors is unknown. Methods Immunohistochemistry for perilipin 1 and adipophilin was performed in 12 human tooth germs (TG), 27 conventional ameloblastoma (AM), and 8 ameloblastic carcinoma (AC) samples. Cytoplasmic staining was analyzed usi… Show more

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Cited by 6 publications
(7 citation statements)
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“…The positive results were assessed by semiquantitative scoring. The immunohistochemical analysis of pyroptosis‐related protein expression in the cytoplasm of salivary glands affected by IgG4‐RS was performed using an immunoreactive score (IRS), 16 and the ratio of the number of positive cells to the total number of cells counted was used to quantify the staining 17 …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The positive results were assessed by semiquantitative scoring. The immunohistochemical analysis of pyroptosis‐related protein expression in the cytoplasm of salivary glands affected by IgG4‐RS was performed using an immunoreactive score (IRS), 16 and the ratio of the number of positive cells to the total number of cells counted was used to quantify the staining 17 …”
Section: Methodsmentioning
confidence: 99%
“…Connective and fibrotic tissues were selectively stained blue, nuclei were stained with Weigert's iron haematoxylin and appeared dark brown to black, and the cytoplasm was stained red. in the cytoplasm of salivary glands affected by IgG4-RS was performed using an immunoreactive score (IRS), 16 and the ratio of the number of positive cells to the total number of cells counted was used to quantify the staining. 17 The intensity of expression was scored as follows: 1, weak; 2, moderate; and 3, strong.…”
Section: Masson Trichrome (Mt) Stainingmentioning
confidence: 99%
“…There were 11 studies [10][11][12][13][14][15][16][17][18][19][20] from Asia, three from North America, [21][22][23] four from South America, [24][25][26][27] and one 28 from the Australian population. The age ranges in AB and AC were found to be 11-78 years 11,13,18,20,22,25,28 and 16-72 years, respectively.…”
Section: Study Characteristics Clinical Featuresmentioning
confidence: 99%
“…Nineteen articles studied 41 markers [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] which could be categorized as proliferative and nonproliferative markers. Ki67, 11,13,15,22,23,24 AgNOR, 15,25 PCNA, 12 and p53 22,24 are all proliferative markers.…”
Section: Immunohistochemical Featuresmentioning
confidence: 99%
“…Except for the above diseases and tumours, adipophilin has been detected in malignant melanoma, ameloblastic carcinoma, salivary gland secretory carcinoma, mammary analogue secretory carcinoma, and brain ageing and neurodegeneration 24 49. However, its diagnostic role for these diseases is not yet clear.…”
Section: Introductionmentioning
confidence: 99%