Seasonal changes of humoral and cellular immune responses to Japanese cedar (<i>Cryptomeria japonica</i>) pollen allergens in Japanese monkeys (<i>Macaca fuscata</i>) with pollinosis

Sakaguchi, Masahiro; Yamada, Tomoko; Hirahara, Kazuki; Shiraishi, Akio; Sakai, Saburo; Miyazawa, Hiroshi; Taniguchi, Yoshifumi; Inouye, Sakae; Nigi, Hideo

doi:10.1034/j.1600-0684.2001.300207.x

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…Allergic rhinitis has been reported in an adult female chimpanzee (Halpern et al, 1989;Dumonceaux et al, 1997) and Japanese macaques (M. fuscata) (Sakaguchi et al, 1992(Sakaguchi et al, , 1999. The report of pollinosis in Japanese macaques (Sakaguchi et al, 1992) describes specific serum IgE to allergens from Japanese cedar trees and refers to reports indicating pollinosis in both wild and captive Japanese macaques throughout Japan. The tested monkeys had clinical signs of sneezing, rhinorrhea, pruritus, and epiphora.…”

Section: Rhinitis Nasal Polyposis and Sinusitismentioning

confidence: 99%

Respiratory System Diseases of Nonhuman Primates

Lowenstine

Osborn

2012

Nonhuman Primates in Biomedical Research

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Section: Rhinitis Nasal Polyposis and Sinusitismentioning

confidence: 99%

Respiratory System Diseases of Nonhuman Primates

Lowenstine

Osborn

2012

Nonhuman Primates in Biomedical Research

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“…In addition to human CJ pollinosis, sensitivity to CJ pollen has also been found in monkeys 7 and dogs 8,9 . The antigen‐specific responses in monkeys were shown to be similar to those in human patients: positive responses to a crude extract of CJ pollen and the two major CJ allergens were documented using in vivo and in vitro methods such as intradermal testing, IgE measurement, histamine release test and lymphocyte proliferation test 7 . In dogs, sensitivity to CJ pollen allergen was first demonstrated by in vivo tests including Prausnitz‐Küstner testing, intradermal testing and provocation testing 8 .…”

Section: Introductionmentioning

confidence: 99%

Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar (Cryptomeria japonica) pollen

Masuda

Sakaguchi

Sakai

et al. 2002

Veterinary Dermatology

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Three dogs were examined because of episodes of recurrent pruritic dermatitis in the spring, the season of Japanese cedar (Cryptomeria japonica, CJ) pollination in Japan. The dogs were shown to be sensitive to CJ pollen allergen using intradermal testing and antigen-specific IgE measurement. Fluorometric enzyme-linked immunosorbant assay (ELISA) showed increased concentrations of IgE specific to Cry j 1 and a negative result for Cry j 2 in the three dogs. The concentrations of IgE specific to Cry j 1 during the season of CJ pollination were higher than the concentrations found during the off-season in all the dogs, and the variation in the concentrations correlated with the variation in clinical signs. Peripheral blood mononuclear cells showed apparent proliferative responses to crude CJ pollen antigen and Cry j 1 during CJ pollination season. These findings indicated that Cry j 1 was the major allergen recognized by IgE and lymphocytes and resulted in the development of type I hypersensitivity to CJ pollen allergen in these atopic dogs.

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“…There have been a limited number of reports on spontaneous allergic rhinitis in animals. Although reports on spontaneous rhinitis associated with CJ pollinosis in the monkey [14] and cat [5] revealed in vivo and in vitro evidences of type I hypersensitivity to CJ pollen antigen in the affected animals, there has been no report on spontaneous allergic rhinitis attributed to HDM in animals. In the dog, as shown in the present study, AR might be provoked by sensitization to HDM with cytokine production skewed to T H 2-type.…”

Section: Discussionmentioning

confidence: 99%

Immunological Findings in 3 Dogs Clinically Diagnosed with Allergic Rhinitis

et al. 2004

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ABSTRACT. Three dogs clinically diagnosed with allergic rhinitis (AR) were examined for their immunological findings. House dust mites (HDM) such as Dermatophagoides farinae (DF) and D. pteronyssinus (DP) were identified as positive allergens in the 3 dogs with both intradermal skin test and serum antigen-specific IgE test. Lymphocyte blastogenic response of peripheral blood mononuclear cells (PBMCs) under stimulation with DF antigen in dogs with AR was higher than that in 4 healthy control dogs. Expression level of IL-4 mRNA in PBMCs obtained from the 3 AR dogs was higher than that in PBMCs obtained from 4 healthy control dogs before and after stimulation with DF antigen. Expression level of IFN-γ mRNA in PBMCs was not different between the AR and control dogs before and after stimulation with DF antigen. These results suggested that allergic reaction to HDM antigen and T H 2-type immune response were associated with the development of AR in 3 dogs examined in this study. KEY WORDS: allergic rhinitis, canine, house dust mite, T H 2-type immune response.

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Seasonal changes of humoral and cellular immune responses to Japanese cedar (Cryptomeria japonica) pollen allergens in Japanese monkeys (Macaca fuscata) with pollinosis

Cited by 7 publications

References 22 publications

Respiratory System Diseases of Nonhuman Primates

Respiratory System Diseases of Nonhuman Primates

Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar (Cryptomeria japonica) pollen

Immunological Findings in 3 Dogs Clinically Diagnosed with Allergic Rhinitis

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