Immunological Findings in 3 Dogs Clinically Diagnosed with Allergic Rhinitis

Abstract

ABSTRACT. Three dogs clinically diagnosed with allergic rhinitis (AR) were examined for their immunological findings. House dust mites (HDM) such as Dermatophagoides farinae (DF) and D. pteronyssinus (DP) were identified as positive allergens in the 3 dogs with both intradermal skin test and serum antigen-specific IgE test. Lymphocyte blastogenic response of peripheral blood mononuclear cells (PBMCs) under stimulation with DF antigen in dogs with AR was higher than that in 4 healthy control dogs. Expression level of IL-4 mRNA in PBMCs obtained from the 3 AR dogs was higher than that in PBMCs obtained from 4 healthy control dogs before and after stimulation with DF antigen. Expression level of IFN-γ mRNA in PBMCs was not different between the AR and control dogs before and after stimulation with DF antigen. These results suggested that allergic reaction to HDM antigen and T H 2-type immune response were associated with the development of AR in 3 dogs examined in this study. KEY WORDS: allergic rhinitis, canine, house dust mite, T H 2-type immune response.

Increased proportions of CCR4⁺ cells among peripheral blood CD4⁺ cells and serum levels of allergen-specific IgE antibody in canine chronic rhinitis and bronchitis

“…Canine chronic rhinitis (CR) and bronchitis (CB) are also suspected to be allergic diseases, and their clinical signs of nasal water discharge, sneezing and cough may become incurable and intractable diseases due to an atopic predisposition [ 5 , 14 , 25 ]. However, it is usually difficult to diagnose allergic and atopic predispositions in dogs with naturally occurring CR and CB.…”