Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar ( Cryptomeria japonica ) pollen

105

Fourteen dogs with known clinical hypersensitivity to soy and corn were maintained on a limited antigen duck and rice diet until cutaneous manifestations of pruritus were minimal (78 days). Sequential oral challenges with cornstarch, corn and soy were then performed. Subsequently, the dogs were fed a diet containing hydrolysed soy protein and cornstarch. Throughout the study period the dogs were examined for cutaneous manifestations of pruritus and, additionally, serum was collected for measurement of allergen-specific and total immunoglobulin (Ig)E concentrations. Intradermal testing with food antigens was performed prior to entry into the study and after 83 days. A statistically significant clinical improvement was measured between days 0 and 83. Significant pruritus was induced after oral challenge with cornstarch, corn and soy (P = 0.04, 0.002, 0.01, respectively) but not with the hydrolysed diet (P = 0.5). The positive predictive value of the skin test for soy and corn allergy was reduced after feeding a soy and corn free diet. Although increases in soy and corn-specific serum IgE concentrations were measured in individual dogs post challenge they were not statistically significant and could not be used to predict clinical hypersensitivity.

Section: Discussionsupporting

confidence: 82%

Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy

Jackson¹,

Jackson²,

Coblentz³

et al. 2003

105

“…There are intrinsic and extrinsic factors that reportedly influence total or allergen‐specific IgE concentrations in the sera of dogs, although not all studies support these findings . The present study did not demonstrate any correlation between age, gender, vaccination status or recent desensitization and total IgE concentrations.…”

Section: Discussionmentioning

confidence: 99%

Total andToxocara canislarval excretory/secretory antigen‐ and allergen‐specific IgE in atopic and non‐atopic dogs

Zwickl

Joekel

Fischer

et al. 2018

“…In the present study, serum samples were collected from the majority of nonatopic dogs in winter, whereas they were collected from atopic dogs throughout the year. In humans, season is unlikely to cause false‐positive reactions in allergen‐specific IgE tests; 33 however, mixed results have been reported in dogs 34,35 . Exposure to indoor allergens, such as house dust mites, which are commonly associated with canine AD, is usually perennial.…”

Section: Discussionmentioning

confidence: 99%

High allergen‐specific serum immunoglobulin E levels in nonatopic West Highland white terriers

Roque¹,

O’Leary²,

Kyaw-Tanner³

et al. 2011

Human and canine atopic dermatitis (AD) share an association with IgE specific to environmental allergens, but few studies have evaluated serum allergen-specific IgE in nonatopic dogs. This study compared serum allergen-specific IgE levels in 30 atopic and 18 nonatopic West Highland white terriers. Atopic dermatitis was confirmed using standard criteria. Nonatopic dogs were over 5 years of age and had no clinical signs or history of AD. Serum allergen-specific IgE levels were measured with Allercept(®) IgE ELISAs using a 48-allergen Australian panel. Positive reactions were defined as ≥150 ELISA absorbance units. Intradermal tests were performed in 16 atopic dogs, either at the time of or at various times prior to serum collection. In atopic dogs, the most common positive ELISA and intradermal test results were to Dermatophagoides farinae (11 of 30 dogs), but there were no statistically significant correlations between results from the two methods for any allergen. In nonatopic dogs, multiple high-positive ELISA reactions were reported to 45 of 48 allergens, most commonly D. farinae and Tyrophagus putrescentiae (17 of 18 dogs each). Positive ELISA results in nonatopic dogs were statistically significantly higher than those in atopic dogs for 44 of 48 allergens, including two allergens (D. farinae and Dermatophagoides pteronyssinus) commonly regarded as significant in canine AD. In conclusion, positive allergen-specific IgE ELISAs were not specific for canine AD, and high allergen-specific IgE levels were seen in nonatopic dogs. The clinical significance of this and whether it characterizes a protective phenotype is unclear.