Screening zum Antibiotika-Transfer aus dem Boden in Getreide in Regionen Nordrhein-Westfalens mit großen Viehbeständen

Freitag, M; Yolcu, D. H.; Hayen, Heiko; Betsche, Thomas; Grote, Manfred

doi:10.1007/s00003-008-0329-5

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…). The occurrence of these degradation products is in accordance with previously reported results of CTC uptake in wheat, where TC, CTC, ICTC and DMC also were detected . Similarly, TC and ETC were found in pinto beans treated with TC only .…”

Section: Discussionsupporting

confidence: 92%

“…Most investigations analyzing antibiotic contamination of wheat plants and more specifically wheat grain had experimental set‐ups involving hydroponic cultures or pot and field experiments, where certain substrates containing various antibiotics and other contaminants have been applied . With respect to agricultural practice, the only existing work, as far as we are aware, reported that 11 of 23 analyzed wheat grain samples were found to be positive for tetracyclines . Analyzing 371 wheat and rye grain samples originating from areas spanning several German federal states and three growing seasons, a deeper insight was gained into the tetracycline contamination of these grains from agricultural practice.…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, no antibiotic residues could be detected in wheat grain, when plants had been grown on experimental plots fertilized with dewatered municipal biosolids containing among other contaminants tetracyclines and fluoroquinolones. 18 With a focus on areas with a high life stock concentration in Germany and correspondingly high application levels of slurry, to the best of our knowledge, Freitag et al 19 are the only researchers who were able to demonstrate an uptake of tetracyclines in wheat grain in 11 of 23 analyzed samples from agricultural practice. Tetracyclines are a group of antibiotics used at high amounts in animal husbandry, which comprise tetracycline (TC), chlortetracycline (CTC), doxycycline (DOC) and oxytetracycline (OTC) ( Fig.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the different tetracyclines, various metabolites of these substances can be detected in wheat grain. 19,20 The present study aimed to obtain a broader data basis concerning the occurrence of various (chlor)tetracycline residues in wheat and rye grains originating from agricultural practice in Germany over three growing seasons. In parallel, CTC uptake experiments with wheat were performed under controlled growing conditions using hydroponic cultures.…”

Section: Introductionmentioning

confidence: 99%

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Chlortetracycline and related tetracyclines: detection in wheat and rye grain

Schwake-Anduschus

Langenkämper

2018

J Sci Food Agric

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Concentrations of tetracyclines found in wheat and rye grains were of no concern with respect to toxicity regarding human consumption. However, antibiotic concentrations below the minimum inhibitory concentration can select for antibiotic resistance in bacteria. Thus, low levels of different tetracycline residues contained in food should be taken into account regarding risk assessment. © 2018 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chlortetracycline and related tetracyclines: detection in wheat and rye grain

Schwake-Anduschus

Langenkämper

2018

J Sci Food Agric

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“…Die in vivoBildung dieser Komponenten ist in der Nährlösung und/oder während der Probenvorbereitung und Nachweisgrenze (TC). Daher kann davon ausgegangen werden, dass die in den einzelnen Pflanzenabschnitten neben den zudotierten Wirkstoffen nachgewiesenen zusätzlichen Komponenten überwiegend in vitro, also nach der Aufnahme über die Wurzel in den Pflanzen gebildet worden sind (Grote et al 2006;Freitag et al 2008).…”

Section: Analyse Der Hydrokulturpflanzenunclassified

Untersuchungen zum Transfer pharmakologisch wirksamer Substanzen aus der Nutztierhaltung in Porree und Weißkohl

et al. 2009

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Investigation on the transfer of pharmacologically active substances used in animal husbandry into leek and cabbage. The potential of leek and cabbage for uptake of highly prescribed veterinary drugs (antibiotics) was tested in hydroponically grown plants. For this purpose the antibiotics sulfadiazine (SFD), enrofloxacine (ENR), tetracycline (TC), chlortetracycline (CTC) and monensine (MON) were chosen. A further aim was to gain data on the situation of vegetables grown in agricultural practise with regard to antibiotic residues. The evident effects of the antibiotics on plants grown hydroponically (each antibiotic was administered at 5 lmol/l nutrient solution) were greatly different: With regard to leek there were no visible effects (MON, SFD), a weak bleaching of the younger leaf sections (CTC), and strong effects of ENR. The (phytotoxic) effects of antibiotics on cabbage were much more distinct. CTC caused a yellowing of the plant vasculature in cabbage. MON induced lesions on some leaves and finally led to leaf wilting. With administration of ENR a nearly complete bleaching of young leaves was observed. Using LC-MS/MSmethods (low-resolution and high-resolution MS) the administered antibiotics, as well as conversion products and metabolites, were separately identified and quantified in various organs of leek (roots, young and old sections of leaves) and cabbage (roots, stalks, young and old leaves). Depending on the type of antibiotic, vegetable species, and plant organ, the detected concentrations of antibiotic residues comprised several orders of magnitude ranging from lg/kg to mg/kg of fresh weight (fw). The highest concentrations of antibiotics were found in roots of both vegetable species: CTC and TC were detected at approximately 10 mg/kg fw in cabbage roots and at approximately 20 mg/kg fw in leek roots and ENR was determined at approximately 12 mg/kg fw in cabbage roots. Low amounts of ENR were metabolised to ciprofloxacine (CIP). ENR occurred at similar concentrations of approximately 7 mg/kg fw in roots and old leaves of cabbage, indicating a high transport rate of this antibiotic in the cabbage plant. In stalks, young and old leaves of cabbage and in young and old leaf sections of leek all administered antibiotics were detected. Within these antibiotics, ENR and CTC and their conversion products, e. g. demeclocycline (DMC) and TC, occurred at the highest concentrations. SFD and MON were found in considerably lower concentrations (\100 lg/kg fw). The results of our experiments in hydroponic cultures, using defined concentrations of antibiotics in the nutrient solution, evidently demonstrate that

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