Screening transplant donors for HTLV-1 and -2

Gallo, Robert C.; Willems, Luc; Hasegawa, Hideki

doi:10.1182/blood-2016-09-739433

Cited by 40 publications

(23 citation statements)

References 17 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adult T‐cell leukemia/lymphoma (ATLL) is a rare and extremely aggressive T‐cell neoplasm with a dismal prognosis. The disease is caused by the retrovirus human T‐cell leukemia virus type 1 (HTLV‐1), which is endemic in southwestern Japan, sub‐Saharan Africa, South America, the Caribbean region, and certain areas in the Middle East and Australia . HTLV‐1 is also prevalent at low levels in the United States .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and survival trend of adult T‐cell leukemia/lymphoma in the United States

Shah

Qiao

et al. 2019

Cancer

View full text Add to dashboard Cite

Background Globally, 5 million to 10 million people are infected with human T‐cell leukemia virus type 1, which causes adult T‐cell leukemia/lymphoma (ATLL) in 2% to 5% of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging to diagnose. Very little data exist on the incidence patterns of ATLL in the United States. Methods ATLL cases reported to the National Program of Cancer Registries, the Surveillance, Epidemiology, and End Results (SEER) program, and the New York State Cancer Registry were used for the study. Age‐adjusted incidence rates were calculated by age, race/ethnicity, sex, and year of diagnosis. The 5‐year survival rate was compared among race/ethnicity groups with the SEER data. Results During 2001‐2015, 2148 ATLL cases were diagnosed in the United States, 18% of which were in New York State. New York State had the highest incidence rate for ATLL, with a rising trend especially among non‐Hispanic blacks (NHBs), whereas the incidence was stable across the remainder of the United States. NHBs were diagnosed at a younger median age (54 years) and had a shorter overall survival (6 months). In New York City, only 22.6% of the ATLL cases diagnosed were born in North America. Conclusions This is the largest epidemiological study of ATLL in the United States and shows a rising incidence in New York City. NHBs have a younger age at presentation and poor overall survival. The rising incidence is largely due to NHBs originating from the Caribbean.

show abstract

Section: Introductionmentioning

confidence: 99%

Epidemiology and survival trend of adult T‐cell leukemia/lymphoma in the United States

Shah

Qiao

et al. 2019

Cancer

View full text Add to dashboard Cite

show abstract

“…Human T-cell leukemia virus type 1 (HTLV-1) and -2 (HTLV-2) belong to the Primate T Lymphotropic Virus group (PTLV), sharing common epidemiological and biological properties, and in particular T-lymphocytes tropism [ 1 ]. Isolated in 1980, HTLV-1 is the causative agent of adult T-cell leukemia/lymphoma (ATL) [ 2 ] and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Revisiting human T-cell lymphotropic virus types 1 and 2 infections among rural population in Gabon, central Africa thirty years after the first analysis

Caron¹,

Besson²,

Padilla³

et al. 2018

PLoS Negl Trop Dis

View full text Add to dashboard Cite

HTLV-1 infection is considered as highly endemic in central Africa. Thirty years ago, a first epidemiological study was performed in Gabon, central Africa, and revealed that the prevalence varied from 5.0 to 10.5%. To evaluate current distribution of HTLVs in Gabon, 4.381 samples were collected from rural population living in 220 villages distributed within the 9 provinces of country. HTLVs prevalence was determined using two ELISA tests and positive results were confirmed by Western Blot. The overall HTLV-1 seroprevalence was of 7.3% among the rural Gabonese population; with 5.4% for men and 9.0% for women. Prevalence of HTLV-1 differed by province, ranging from 2.3% to 12.5% into the rain forest. Being a woman older than 51 years represented a high risk for HTLV-1 acquisition. Hospitalization, operation/surgery, transfusion and medical abortion or fever, arthritis and abdominal pain are also significant risk factors. In addition, 0.1% of samples were found as HTLV-2 positive, while 12.0% had an indeterminate HTLV serological pattern. HTLV-3 and HTLV-4 were not found. Phylogenetic analysis was performed on 87 samples and demonstrated that HTLV-1 present in Gabon belongs mostly to subtype B, however the rare subtype D was also found. Altogether, our results demonstrate that almost thirty years after the first epidemiological study prevention of HTLVs infection is still an issue in Gabon.

show abstract

“…Of note, the Global Virus Network Task Force on HTLV-1 recommends that transplant societies should make extensive use of screening assays and should instruct donors and recipients about HTLV-1/2 infection, transmission, and disease prevention, as high rates of ATLL and HAM have been detected in HTLV-1-infected patients after organ transplantation ( Gallo et al 2016 ).…”

mentioning

confidence: 99%

Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C

Caterino–de–Araujo

Alves

Campos

et al. 2018

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

With this study, the authors hope to alert clinicians regarding the presence of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/-2) infections in patients with viral hepatitis B and C in Brazil. HTLV-1/-2 were detected in 1.3% of hepatitis B virus (HBV)- and 5.3% of hepatitis C virus (HCV)-infected blood samples sent for laboratory viral load measurements. A partial association of human immunodeficiency virus (HIV)-1 and HTLV-1/-2 infection was detected in patients with HCV (HIV+, 27.3%), whereas this association was almost 100% in HBV-infected patients (HIV+, all except one). The high prevalence of HTLV-1/-2 infection among patients with hepatitis C was of concern, as HTLV-1/-2 could change the natural course of subsequent liver disease. The authors suggest including HTLV-1/-2 serology in the battery of tests used when following patients with viral hepatitis in Brazil, regardless of the HIV status.

show abstract

Screening transplant donors for HTLV-1 and -2

Cited by 40 publications

References 17 publications

Epidemiology and survival trend of adult T‐cell leukemia/lymphoma in the United States

Epidemiology and survival trend of adult T‐cell leukemia/lymphoma in the United States

Revisiting human T-cell lymphotropic virus types 1 and 2 infections among rural population in Gabon, central Africa thirty years after the first analysis

Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C

Contact Info

Product

Resources

About