Epidemiology and survival trend of adult T‐cell leukemia/lymphoma in the United States

Abstract

Background Globally, 5 million to 10 million people are infected with human T‐cell leukemia virus type 1, which causes adult T‐cell leukemia/lymphoma (ATLL) in 2% to 5% of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging to diagnose. Very little data exist on the incidence patterns of ATLL in the United States. Methods ATLL cases reported to the National Program of Cancer Registries, the Surveillance, Epidemiology, and End Results (SEER) program, and the New York State Cancer Registry were used for the study. Age‐adjusted incidence rates were calculated by age, race/ethnicity, sex, and year of diagnosis. The 5‐year survival rate was compared among race/ethnicity groups with the SEER data. Results During 2001‐2015, 2148 ATLL cases were diagnosed in the United States, 18% of which were in New York State. New York State had the highest incidence rate for ATLL, with a rising trend especially among non‐Hispanic blacks (NHBs), whereas the incidence was stable across the remainder of the United States. NHBs were diagnosed at a younger median age (54 years) and had a shorter overall survival (6 months). In New York City, only 22.6% of the ATLL cases diagnosed were born in North America. Conclusions This is the largest epidemiological study of ATLL in the United States and shows a rising incidence in New York City. NHBs have a younger age at presentation and poor overall survival. The rising incidence is largely due to NHBs originating from the Caribbean.

Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review

“…Human T-cell leukemia virus type 1 causes ATLL in about 5% of the carriers [32]. In the United States, the incidence of ATLL was stable but showed a rising trend in the New York City, which is largely due to non-Hispanic blacks originating from the Caribbean [33]. In our study, the five primary ATLL patients were all Taiwanese.…”

Leucemia Mieloide E Linfoide: Taxa De Mortalidade No Estado Do Pará-Brasil Entre Os Anos De 2000 E 2017

“…A sobrevida de pacientes com leucemia melhorou muito nos últimos anos, embora em graus variáveis, o que resultou em diferenças significativas quanto à idade e raça. A melhora da sobrevida em todos os pacientes provavelmente reflete os diagnósticos e avanços terapêuticos, como melhorias nos diagnósticos celulares e moleculares, estadiamento, terapias direcionadas e transplante de células hematopoiéticas (SHAH et al, 2020). O acesso desigual a esses avanços pode potencialmente estar subjacente às disparidades de sobrevivência entre os grupos (idade e raça), bem como fatores biológicos e não biológicos (WEI et al, 2018).…”

Over-representation of MEF-2 isoforms (A/C) is associated with HTLV-1-induced acute ATLL and their recruitment to 3’LTR facilitates HBZ expression from the antisense promoter via interactions with Menin and Jun D

“…Patient samples and primary cells. Samples from NA-ATLL patients, as published (22,23,56), were obtained from the Albert Einstein College of Medicine (NY, USA). In addition, samples from 11 HTLV-1-associated myelopathy/Tropical spastic paraparesis (HAM/TSP) patients (82% female) and 10 asymptomatic HTLV-1-infected individuals (60% female) were studied.…”