Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review

Liu, Kwei-Lan; Tsai, Wen-Chien; Lee, Chih‐Hung

doi:10.1371/journal.pone.0228046

Cited by 5 publications

(14 citation statements)

References 42 publications

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“…Nonetheless, ethnic and environmental factors may have influenced this disease distribution. 17,18 In harmony with previous reports, 17,18,26 about 5% of our patients had blood involvement, 17% presented with T3 and T4 skin lesions, 22% revealed significant peripheral lymph nodes and most MF patients (79.6%) were presented at an early stage (IA and B).…”

Section: Discussionsupporting

confidence: 90%

“…The potential utility of these markers to differentiate CTCL from its mimickers is also addressed with the secondary aim to highlight the demographic profiles, relative frequencies, common clinicopathological features and staging distribution of this relatively rare entity in our locality. Demographically, CTLC patients had a lower mean age as compared to worldwide studies, 1,[16][17][18] but matched one national study. 10 However, dermatoses patients exhibited the average mean age defined for these conditions.…”

Section: Discussionmentioning

confidence: 61%

“…[19][20][21] Lymphomas predominated in males, while the dermatoses dominated in females as reported in previous studies. 1,17,22 According to the WHO-EORTC classification, MF comprised 83% of CTCLs of which 32.6% were MF variants. Patch MF was the most frequent classic MF clinical form, while erythrodermic MF was the least frequently encountered form.…”

Section: Discussionmentioning

confidence: 99%

“…1,12,22 In contrast, hypopigmented MF commonly presents as asymptomatic macules or patches at stage I and slowly progresses over many years. 23 For non-MF CTCLs, skin involvement of multiple anatomical sites is a limiting poor prognostic factor, 17 while PTCL patients commonly have an unfavorable International Prognostic Index (IPI). 27 In the past decade, the prognostic role of proliferation and angiogenesis markers has been investigated in CTCL, but has not yet been confirmed.…”

Section: Discussionmentioning

confidence: 99%

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<p>Ki67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement</p>

Zohdy¹,

hafez²,

Allah³

et al. 2020

CCID

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Background: Cell proliferation and angiogenesis are important in progression of cancerous processes. Differentiating cutaneous T-cell lymphoma (CTCL) from its mimicking dermatoses and prognosticating it are challenging. Aim: This study assesses cell proliferation and angiogenesis in different CTCL subtypes using immunohistochemistry (IHC) for Ki67 and CD31 to testify their usability in differentiating CTCL from mimicking dermatoses and discriminating CTCL subtypes from each other with correlation to clinicopathological parameters and disease advancement. Patients and Methods: IHC for Ki67 and CD31 were applied to skin biopsies from 81 patients divided into CTCL (n=59) and dermatoses (n=22) groups. Hot-spot analysis was used to score Ki67 and CD31 microvascular density (MVD) semiquantitatively. Statistical analysis was performed to compare Ki67 index and MVD between CTCL and dermatoses. CTCL subgroups were compared to each other. Ki67 index and CD31 were compared to age, gender, skin and nodal involvement, blood tumor burden and TNMB stage. Results and Conclusion: There were significant differences in proliferation index and MVD between dermatoses and CTCL, and between dermatoses and all CTCL subtypes with exception of Ki67 in early mycosis fungoides (MF) and CD31 in patch lesions. Increased cell proliferation and MVD were significantly associated with older age, T3 and 4 skin involvement, significant nodes (N1-3), positive blood tumor burden (B1,2) in CTCL and TNMB stage of MF. Both markers differentiated significantly late from early MF, classic MF from its variants and non-MF CTCL from total MF, but not from late MF. In conclusion, Ki67 and CD31 expression in skin biopsies using IHC reproduces the role of proliferation and angiogenesis in the differential diagnosis and prognostication of CTCL being expressed at higher levels in aggressive than indolent CTCL. Therapeutic targeting of cell proliferation and angiogenesis may improve patient's outcome in CTCL. Usability of these markers into patient's stratification should be considered in further studies.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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<p>Ki67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement</p>

Zohdy¹,

hafez²,

Allah³

et al. 2020

CCID

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“…Regarding extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT), several authors have indicated a higher frequency of this condition in Asian countries compared to in Western countries and a strong association between Epstein-Barr virus (EBV) and ENKTCL in Asian populations [ 33 – 35 ]. However, we found only 1 case (0.7%) of ENKTCL-NT in our study, which was lower than reported in other Asian countries [ 8 – 10 , 36 ]. In our center experience, many patients with ENKTCL-NT present with extracutaneous manifestations, this can be the explanation of a low rate of primary cutaneous ENKTCL-NT.…”

Section: Discussioncontrasting

confidence: 92%

Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study

Pruksaeakanan

Teyateeti

Patthamalai

et al. 2021

BioMed Research International

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Background. Primary cutaneous lymphomas (PCLs) refer to cutaneous lymphomas that primarily develop in the skin with no evidence of extracutaneous disease at the time of diagnosis. The epidemiological and clinical data of PCLs in Thailand are lacking. Objectives. To evaluate the frequency, demographic data, and clinical characteristics of different subtypes of PCLs in a tertiary care university hospital. Methods. In total, 137 patients with PCLs diagnosed in our hospital in 2008–2017 were retrospectively reviewed. Results. Of the 137 patients, 57 (41.6%) were male and 80 (58.4%) were female ( M : F = 1 : 1.4 ). The median age at diagnosis was 40 years. Most patients (134, 97.8%) had cutaneous T-cell lymphomas (CTCLs). Three patients (2.2%) had cutaneous B-cell lymphomas (CBCLs). The most common subtype was mycosis fungoides (MF) (67.9%), followed by subcutaneous panniculitis-like T-cell lymphoma (SPTCL) (21.2%), primary cutaneous anaplastic large cell lymphoma (pcALCL) (3.6%), lymphomatoid papulosis (LyP) (1.5%), primary cutaneous gamma/delta T-cell lymphoma (pcGDTCL) (1.5%), Sézary syndrome (SS) (0.7%), extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) (0.7%), primary cutaneous peripheral T-cell lymphoma, not otherwise specified (pcPTCL-NOS) (0.7%), primary cutaneous diffuse large B-cell lymphoma, leg type (pcDLBCL-LT) (1.5%), and primary cutaneous follicle center lymphoma (pcFCL) (0.7%). Most patients with MF presented with early-stage disease (84.0%), with hypopigmented MF the most common variant (42.6%). Conclusions. Compared to earlier Caucasian and Asian studies, the present study revealed a higher proportion of CTCL patients with a younger age at onset and a female predominance. MF was the most common CTCL subtype, followed by SPTCL. More than 80% of MF patients were diagnosed at an early stage.

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Distribution and clinical features of lymphomas involving skin in Taiwan

Chang

Lee

et al. 2023

The Kaohsiung J of Med Scie

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A wide variety of primary and secondary lymphoma types involves the skin. However, reports with comparisons between both groups are limited in Taiwan. We retrospectively enrolled all cutaneous lymphomas and evaluated their clinicopathologic features. There were 221 cases of lymphoma: 182 (82.3%) primary and 39 (17.7%) secondary. Mycosis fungoides was the most common primary T-cell lymphoma, 92 (41.7%) cases, followed by CD30-positive T-cell lymphoproliferative disorders including lymphomatoid papulosis (n = 33, 14.9%) and cutaneous anaplastic large cell lymphoma (n = 12, 5.4%). The most frequent primary B-cell lymphomas were marginal zone lymphoma (n = 8, 3.6%) and diffuse large B-cell lymphoma (DLBCL), leg type (n = 8, 3.6%). DLBCL including variants was the most common secondary lymphoma involving skin. Most primary lymphomas presented at low-stage (T-cell, 86%; B-cell, 75%), whereas the majority of secondary lymphomas presented at high-stage (T-cell, 94%; B-cell, 100%). Patients with secondary lymphomas had an older mean age, more frequent B symptoms, lower serum albumin and hemoglobin, and a higher frequency of atypical lymphocytes in blood than those with primary lymphomas. In primary lymphomas, older age, lymphoma types, decreased lymphocyte counts and

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Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review

Cited by 5 publications

References 42 publications

<p>Ki67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement</p>

<p>Ki67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement</p>

Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study

Distribution and clinical features of lymphomas involving skin in Taiwan

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