Screening study of enzymatic inhibition of medicinal plants for the treatment of diabetes using a glucometer biosensor approach and optical method

A systematic review of the inhibitory effect of extracts from edible parts of nuts on α-glucosidase activity

“…The data between the studies is difficult to compare, since different nut varieties, extraction methods, enzyme assay substrates and/or enzyme amounts were used in each. The water extract in the study by Attaallah et al 55 demonstrated the lowest inhibition of yeast α-glucosidase by almonds, while water extracts of heckle seeds ( Ricinodendron heudelotii ), known commonly as the African nut-tree, also exhibited low inhibitory potential. 66 A fifth study on almonds involved testing peptides purified from the residue of almond oil from the Siberian apricot ( Armeniaca sibirica ), which belongs to a subgroup of the Prunus genus.…”

“…, phytochemical), of the test inhibitors used. 55,63 Two studies also failed to provide the nut origin/supplier, 17,55 while 40% of studies were lacking this information for other solvents and reagents used throughout the extraction process and/or enzyme assay, and three studies lacked details on the nut extraction method ( e.g. , solvent, time and temperature).…”

“…Also, the absence of acarbose as a positive control in eight studies complicates the comparison between various nut extracts. 53,55–57,59,60,66 Due to the small number of included studies for rat enzyme inhibition, it is difficult to determine whether compounds in nut extracts are effective inhibitors of mammalian α-glucosidase.…”

“…Full texts of all articles were obtained to retrieve detailed study characteristics. A total of 15 papers met all inclusion criteria; 17,18,[53][54][55][56][57][58][59][60][61][62][63][64][65] 10 studies examined the inhibitory effect on α-glucosidase activity of polyphenol-rich extracts, four studies examined the effects of isolated protein/ peptides and one study used nuts extracted in hot water with no further extraction applied (Tables 1 and 2). Of the included studies, no studies reported the effect of nut extracts on human α-glucosidase, two studies examined rat α-glucosidase activity (Table 1), and 13 articles used α-glucosidase from yeast (Table 2).…”

A bibliometric approach to preclinical studies of Tinospora crispa (L.) Hook. f. & Thomson as an antidiabetic

“…The DM incidence has constantly increased over time, with 463 million patients in 2019, and it is estimated to grow to 578 million and 700 million by 2030 and 2045, respectively. Besides the high prevalence, DM becomes a health burden, decreasing the quality of life, causing death, and affecting economic costs (Attaallah et al, 2021). We can apply natural products to prevent and/or treat the disease (Rohman et al, 2020).…”