A systematic review of the inhibitory effect of extracts from edible parts of nuts on α-glucosidase activity

Abstract

Inhibition of α-glucosidases can slow carbohydrate digestion to reduce postprandial glycaemia and lower risk of type 2 diabetes. Our systematic review found no studies that tested the inhibitory potential of nut extracts against human α-glucosidases.

Inhibitory effect of extracts from edible parts of nuts on α-amylase activity: a systematic review

“…A quality assessment of the studies was conducted independently by two authors, MF and MJH, using our previously published modified version of the ToxRTool, 20 with minor modifications (ESI Table 1 †). Briefly, the articles were assessed for quality based on a set of 17 criteria categorised into five assessment domains: test substance identification, test system characterisation, study design description, study results presentation, and the plausibility of the study design and results.…”

“…13,19 We recently conducted a systematic literature review exploring the inhibitory effect of extracts from edible parts of nuts on α-glucosidase activity in vitro but found no studies that tested the inhibitory potential against human α-glucosidases. 20 Our objective in the current study was to systematically review the evidence concerning the impact of extracts of the most commonly consumed parts of nuts on α-amylase activity in vitro, which is the other enzyme central to carbohydrate digestion, and therefore regulation of postprandial glycaemia, in vivo.…”

Screening and Characterization of an α-Amylase Inhibitor from Carya cathayensis Sarg. Peel

“…Glucose undergoes cellular respiration to produce ATP, which cells then utilize to perform various vital functions. Nonetheless, excessive consumption of starch, especially from refined sources, may heighten the risk of chronic conditions, including type 2 diabetes, cardiovascular disease, and specific cancers, attributable to the elevated glycemic index associated with these foods [4,5]. Targeting the digestive mechanisms of starch, specifically through the inhibition of starch hydrolases, offers a promising strategy for promoting foods with a reduced glycemic index [6].…”

Investigating the effect of polyphenols from nuts on human carbohydrate digestion in vitro

“…Almost all studies in this area have been conducted on yeast α-glucosidase, with only a few using rat α-glucosidase. While there is no sequence homology between yeast and human α-glucosidase, there is 74% to 78% sequence homology between rat and human α-glucosidases (1) . The lack of studies on the effect of bioactive compounds from nuts on human α-glucosidases, along with the growing attention to nuts as an important component of a healthy diet with the potential to reduce the risk of chronic diseases (2) , highlights the need for research to evaluate the inhibitory effect of nut extracts on human α-glucosidases.…”

“…Nuts are widely eaten around the world and have the potential to inhibit α-glucosidases through their content of polyphenols and other bioactive compounds. According to our recent systematic review (1) , no study has investigated the inhibitory effects of nut extracts on human α-glucosidase activities. Almost all studies in this area have been conducted on yeast α-glucosidase, with only a few using rat α-glucosidase.…”