Screening of imported malaria infection in asymptomatic migrants from Sub-Saharan Africa: A retrospective analysis of a 2010–2019 cohort

Corbacho-Loarte, María Dolores; Crespillo-Andújar, Clara; Chamorro-Tojeiro, Sandra; Norman, Francesca; Pérez‐Molina, José A.; Martín, Oihane; Rubio, José Miguel; Gullón-Peña, Beatriz; López‐Vélez, Rogelio; Monge‐Maíllo, Begoña

doi:10.1016/j.tmaid.2022.102411

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…In fact, these techniques can detect 0.001–0.01 parasite per microlitre, detecting submicroscopic asymptomatic malaria infection that cannot be diagnosed by thick-smear and thin–film microscopy 15,16 . Molecular tests have been used in several studies for the screening of imported malaria infection in asymptomatic migrants, with prevalence being as high as 14.25%, being more frequent in those who have left malaria-endemic area ≤ 3 years before [ 22 , 23 ]. Therefore, molecular testing seems to be the most accurate technique in detecting malaria infection with existing parasitaemia.…”

Section: Discussionmentioning

confidence: 99%

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Corbacho-Loarte,

Martín,

Chamorro-Tojeiro

et al. 2024

Malar J

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Background In non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety of human blood, the European Union and Spanish national law, requires a deferral period, or a screening by immunological or genomic test among those donors with potential risk of malaria. Scientific societies, European Committee on Blood Transfusion, and Spanish Society of Haematology and Haemotherapy, refer only to the result of the immunological test. Methods An observational retrospective study was performed in potential donors with a positive immunological test for malaria done in the Regional Transfusion Center in Madrid and referred to the National Reference Unit for Tropical Diseases in Madrid between 2015–2020. At consultation a Polymerase Chain Reaction (PCR) for malaria was performed. Results During the study period, 121 possible donors attended for consultation at NRU-Trop. Median age: 38.5 (IQR:33–48); median time to consultation was 32 months (IQR:12.5–110). Eighty-two (67.8%) donors were migrants and thirty-nine were travellers (32.2%). ELISA values were available for 109 subjects (90.1%), 56 individual left malaria endemic area > 3 years before. All donors tested negative for Plasmodium spp PCR test (n = 121, 100%). Conclusions None of the subjects with a positive immunologic test deferred as blood donors had a positive genomic test. The presence of Plasmodium spp in collected blood was not detected by molecular techniques. To avoid the loss of potential blood donors, especially those with low incidence red blood cell antigens, as more precise microbiology techniques become available, updating the existing legislation becomes necessary to increase the availability of donated blood.

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Section: Discussionmentioning

confidence: 99%

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Corbacho-Loarte,

Martín,

Chamorro-Tojeiro

et al. 2024

Malar J

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Updates on Malaria Epidemiology and Prevention Strategies

González-Sanz

Berzosa

Norman

2023

Curr Infect Dis Rep

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Purpose of Review The objective of this review was to provide an update on recent malaria epidemiology, both globally and in non-endemic areas, to identify the current distribution and repercussions of genetically diverse Plasmodium species and summarize recently implemented intervention and prevention tools. Recent Findings Notable changes in malaria epidemiology have occurred in recent years, with an increase in the number of total cases and deaths globally during 2020–2021, in part attributed to the COVID-19 pandemic. The emergence of artemisinin-resistant species in new areas and the expanding distribution of parasites harbouring deletions of the pfhrp2/3 genes have been concerning. New strategies to curb the burden of this infection, such as vaccination, have been implemented in certain endemic areas and their performance is currently being evaluated. Summary Inadequate control of malaria in endemic regions may have an effect on imported malaria and measures to prevent re-establishment of transmission in malaria-free areas are essential. Enhanced surveillance and investigation of Plasmodium spp. genetic variations will contribute to the successful diagnosis and treatment of malaria in future. Novel strategies for an integrated One Health approach to malaria control should also be strengthened.

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Malaria parasite prevalence among migrants: a systematic review and meta-analysis

Requena-Méndez,

Cattaneo,

Bogale

et al. 2023

Clinical Microbiology and Infection

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Screening of imported malaria infection in asymptomatic migrants from Sub-Saharan Africa: A retrospective analysis of a 2010–2019 cohort

Cited by 7 publications

References 25 publications

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Updates on Malaria Epidemiology and Prevention Strategies

Malaria parasite prevalence among migrants: a systematic review and meta-analysis

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