Malaria parasite prevalence among migrants: a systematic review and meta-analysis

Requena-Méndez, Ana; Cattaneo, Paolo; Bogale, Rebecca T.; Marti-Soler, Helena; Wångdahl, Andreas; Buonfrate, Dora; Bisoffi, Zeno; Färnert, Anna; Rodríguez-Cuadrado, Azucena; Monge-Maillo, Begoña; Bocanegra, Cristina; Salvador, Fernando; Oliveira, Ines; Salas-Coronas, Joaquin; Corbacho-Loarte, Maria Dolores

doi:10.1016/j.cmi.2023.09.010

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…In fact, these techniques can detect 0.001–0.01 parasite per microlitre, detecting submicroscopic asymptomatic malaria infection that cannot be diagnosed by thick-smear and thin–film microscopy 15,16 . Molecular tests have been used in several studies for the screening of imported malaria infection in asymptomatic migrants, with prevalence being as high as 14.25%, being more frequent in those who have left malaria-endemic area ≤ 3 years before [ 22 , 23 ]. Therefore, molecular testing seems to be the most accurate technique in detecting malaria infection with existing parasitaemia.…”

Section: Discussionmentioning

confidence: 99%

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Corbacho-Loarte,

Martín,

Chamorro-Tojeiro

et al. 2024

Malar J

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Background In non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety of human blood, the European Union and Spanish national law, requires a deferral period, or a screening by immunological or genomic test among those donors with potential risk of malaria. Scientific societies, European Committee on Blood Transfusion, and Spanish Society of Haematology and Haemotherapy, refer only to the result of the immunological test. Methods An observational retrospective study was performed in potential donors with a positive immunological test for malaria done in the Regional Transfusion Center in Madrid and referred to the National Reference Unit for Tropical Diseases in Madrid between 2015–2020. At consultation a Polymerase Chain Reaction (PCR) for malaria was performed. Results During the study period, 121 possible donors attended for consultation at NRU-Trop. Median age: 38.5 (IQR:33–48); median time to consultation was 32 months (IQR:12.5–110). Eighty-two (67.8%) donors were migrants and thirty-nine were travellers (32.2%). ELISA values were available for 109 subjects (90.1%), 56 individual left malaria endemic area > 3 years before. All donors tested negative for Plasmodium spp PCR test (n = 121, 100%). Conclusions None of the subjects with a positive immunologic test deferred as blood donors had a positive genomic test. The presence of Plasmodium spp in collected blood was not detected by molecular techniques. To avoid the loss of potential blood donors, especially those with low incidence red blood cell antigens, as more precise microbiology techniques become available, updating the existing legislation becomes necessary to increase the availability of donated blood.

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Section: Discussionmentioning

confidence: 99%

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Corbacho-Loarte,

Martín,

Chamorro-Tojeiro

et al. 2024

Malar J

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“…Malaria is a severe infectious disease which is endemic in tropical and subtropical regions [8,9]. It can be caused by four species of the intracellular protozoan parasite from the Plasmodium family, with P. falciparum being the disease's most dangerous form, and it is transmitted by mosquito bites [10].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents

Ribeiro,

Costa,

Pinto

et al. 2023

Marine Drugs

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Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance. There is an urgent need to find new, safe, effective, and affordable antiparasitic drugs. Marine-derived cyclic peptides have been increasingly screened as candidates for developing new drugs. Therefore, in this review, a systematic analysis of the scientific literature was performed and 25 marine-derived cyclic peptides with antiparasitic activity (1–25) were found. Antimalarial activity is the most reported (51%), followed by antileishmanial (27%) and antitrypanosomal (20%) activities. Some compounds showed promising antiparasitic activity at the nM scale, being active against various parasites. The mechanisms of action and targets for some of the compounds have been investigated, revealing different strategies against parasites.

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‘How to manage adult patients with malaria in the non-endemic setting’: author's response

Antinori,

Giacomelli,

Casalini

et al. 2024

Clinical Microbiology and Infection

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Malaria parasite prevalence among migrants: a systematic review and meta-analysis

Cited by 3 publications

References 44 publications

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents

‘How to manage adult patients with malaria in the non-endemic setting’: author's response

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