Screening of Caesalpinia bonduc leaves for antipsoriatic activity

Antipsoriatic activity of extracts and fractions obtained from Memecylon malabaricum leaves

“…The HaCaT cell line contains human keratinocytes and multiplies at a higher than normal rate similar to psoriatic epidermal cells and has been used previously for the evaluation of antipsoriatic drugs [19,23–26] . Human HaCaT keratinocytes were obtained from the National Centre for Cell Sciences, Pune, India and seeded at the concentration of 1.0 × 10 5 cells/ml in a 96‐well microtitre plate and grown in Dulbecco's modified Eagle's medium (DMEM; Gibco, Carlsbad, CA, USA) containing 10% fetal bovine serum (Biowest, Miami, FL, USA).…”

“…Many drugs presently used in the treatment of psoriasis have been evaluated by the mouse tail test and showed good efficacies [18] . Antipsoriatic activity of the extracts of Caesalpinia bonduc were reported using the mouse tail test [19] …”

Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

“…Plant in which in vitro , in vivo, or clinical efficacy has been established are Glycyrrhiza uralensis, Aloe vera (Syed et al, ) , Memecylon malabaricum (Dhanabal, Muruganantham, Basavaraj, Wadhwani, & Shamasundar, ), Capsicum annuum, Psoralea corylifolia , and Mahonia aquifolium. Matricariae flos, Calendulae flos, Hamamelidis folium, Quercus cortex, Violae tricolor, Salviae folium, Echinaceae herba, Dulcamarae stipites, Arnicae flos, Symphyti rhizome, Melaleuca hypericifolia, Melissae folium, Momordica charantia, Azadirachta indica, Arctium lappa, Calendula officinalis, Matricaria recutita, Glycyrrhiza glabra, and Caesalpinia bonduc (Muruganantham et al, ). Plants serve as symptomatic treatment of psoriasis and suppress the disease for a long period.…”

Abortifacient potential of ethanolic seed extract of Caesalpinia bonducella in female albino rats

“…Seeds consist of a thick, brittle shell with a yellowish-white, bitter fatty kernel [8]. It is reported to have multiple therapeutic properties like adaptogenic and antidiabetic [9,10], antifilarial [11], antihelmintic [12], antiinflammatory, antipyretic, and analgesic [13], antimalarial [14], immunomodulatory [15], antibacterial, antifungal, antispasmodic [16], antiproliferative [17], antipsoriatic [18], anticonvulsant [19], antiulcer [20], antivenom [21], and antiurolithiatic [22]. The seeds are found to contain various chemical constituents such as furanoditerpenes, phytosterinin, β-sitosterol, flavonoids, bonducellin, aspartic acid, arginine, citrulline, and β-carotene [23].…”