Screening for Common Neurologic Diseases Among Israeli Adolescents

Bar‐Dayan, Yaron; Arnson, Yoav; Elishkevits, Keren

doi:10.1177/0883073809339878

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…In adults, tic prevalence rates are considerably lower, with estimates of 0.05% to 0.1% for TS, and of 0.08% to 6.7% for any tic disorders (Zohar et al 1992; Apter et al 1993; Robertson et al 1994; Eapen et al 2001; Wenning et al 2005; Bar-Dayan et al 2010; Schlander et al 2011; Knight et al 2012). A Swedish population-based twin study ( n = 21 911) found prevalence rates of 6.7% for having any tic, and 1.4% for having TS (not taking the DSM-IV-TR criterion of presence of at least one vocal tic into account) (Pinto et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Heritability of tic disorders: a twin-family study

et al. 2016

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Background Genetic-epidemiological studies that estimate the contributions of genetic factors to variation in tic symptoms are scarce. We estimated the extent to which genetic and environmental influences contribute to tics, employing various phenotypic definitions ranging between mild and severe symptomatology, in a large population-based adult twin-family sample. Methods In an extended twin-family design, we analyzed lifetime tic data reported by adult mono- and dizygotic twins (n= 8,323) and their family members (n=7,164; parents and siblings) from 7,311 families in the Netherlands Twin Register (NTR). We measured tics by the abbreviated version of the Schedule for Tourette and Other Behavioral Syndromes (STOBS) (TSAICG, 2007). Heritability was estimated by genetic Structural Equation Modeling (SEM) for four tic disorder definitions: three dichotomous and one trichotomous phenotype, characterized by increasingly strictly defined criteria. Results Prevalence rates of the different tic disorders in our sample varied between 0.3 and 4.5% depending on tic disorder definition. Tic frequencies decreased with increasing age. Heritability estimates varied between .25 and .37, depending on phenotypic definitions. None of the phenotypes showed evidence of assortative mating, effects of shared environment, or non-additive genetic effects. Conclusions Heritabilities of mild and severe tic phenotypes were estimated to be moderate. Overlapping confidence intervals of the heritability estimates suggest overlapping genetic liabilities between the various tic phenotypes. The most lenient phenotype (defined only by tic characteristics, excluding criteria B, C and D of DSMIV) rendered sufficiently reliable heritability estimates. These findings have implications in phenotypic definitions for future genetic studies.

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Section: Introductionmentioning

confidence: 99%

Heritability of tic disorders: a twin-family study

et al. 2016

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“…There are a handful of prevalence studies involving adults with TS that could provide some idea of the prevalence of adult-onset tics, but even these are quite few in comparison to the number of prevalence studies done in children 39–46. In three of these studies, the population consisted of adolescents aged 16–17 years who were undergoing health screening for military service in Israel,39,40,46 and therefore not necessarily representative of the 18+ adult population. A few studies have looked at all tic disorders, thereby including secondary tics as well.…”

Section: Prevalencementioning

confidence: 99%