Screening design of experiment applied to supercritical antisolvent precipitation of amoxicillin

Tenorio, A.; Gordillo, María Dolores Gordillo; Pereyra, C.; Ossa, E.J. Martı́nez de la

doi:10.1016/j.supflu.2007.10.009

Cited by 16 publications

(8 citation statements)

References 21 publications

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“…In Figure 2 it is shown a phase equilibrium diagram of the binary system NMP-CO 2 , at two temperatures, estimated using the equation of state of Peng-Robinson, for the system NMP-CO 2 . The data corresponding to this equilibrium diagram were obtained from the development of a computer program in Matllab 7.0 (Tenorio et al, 2008). On the other hand, the presence of the solute can induce changes in the phase diagrams of the binary solvent-SC-CO 2 systems.…”

Section: Solubilitymentioning

confidence: 99%

“…Supercritical antisolvent techniques overcome the main drawbacks of conventional techniques, such as the degradation of the active ingredients because of the high profiles of temperatures and tensile stresses reached and the large amount of organic solvent used, resulting in the need to remove the solvent from the final product. Amoxicillin and ampicillin micronization have been carried out by SAS process in our laboratory (Montes et al, 2010(Montes et al, , 2011Tenorio et al, 2007aTenorio et al, , 2007bTenorio et al, , 2008. Several experiments designs to evaluate the operating conditions influences on the PS and PSD have been made.…”

Section: Pharmaceuticalsmentioning

confidence: 99%

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Particles Formation Using Supercritical Fluids

Montes¹,

Gordillo²,

Pereyra³

et al. 2011

Mass Transfer - Advanced Aspects

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Section: Solubilitymentioning

confidence: 99%

Section: Pharmaceuticalsmentioning

confidence: 99%

Particles Formation Using Supercritical Fluids

Montes¹,

Gordillo²,

Pereyra³

et al. 2011

Mass Transfer - Advanced Aspects

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“…Previously, it was discussed that the different particle formation processes using SCF are classified depending on how the SCF behaves, i.e., the supercritical CO 2 can play the role as antisolvent (AntiSolvent Supercritical process, SAS) or solvent (RESS process). In the facilities of University of Cádiz, amoxicillin and ampicillin micronization have been carried out by SAS process (Montes et al, 2010(Montes et al, , 2011aTenorio et al, 2007aTenorio et al, , 2007bTenorio et al, , 2008. Several experiments designs to evaluate the operating conditions influences on the particle size (PS) and particle size distribution (PSD) have been made.…”

Section: Precipitation With Scfmentioning

confidence: 99%

Hydrodynamics Influence on Particles Formation Using SAS Process

Montes¹,

Tenorio²,

Gordillo³

et al. 2011

Hydrodynamics - Advanced Topics

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“…All parameters that influence the precipitation process (temperature, flow rate, pressure) can be controlled either manually or automatically (using ICM software). All the experiments were performed following the same procedure described in previous works (Tenorio et al 2007(Tenorio et al , 2008. …”

Section: Experimental Equipment and Proceduresmentioning

confidence: 99%

Supercritical Antisolvent Process Applied to the Pharmaceutical Industry

Tenorio

Gordillo

Pereyra

et al. 2010

Particulate Science and Technology

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Pharmaceutical preparations are the final product of a technological process that gives the drugs the characteristics appropriate for easy administration, proper dosage, and enhancement of the therapeutic efficacy. The design of pharmaceutical preparations in nanoparticulate form has emerged as a new strategy for drug delivery (Pasquali, Bettini, and Giordano 2006). Particle size (PS) and particle size distribution (PSD) are critical parameters that determine the rate of dissolution of the drug in the biological fluids and, hence, have a significant effect on the bioavailability of those drugs that have poor solubility in water, for which the dissolution is the rate-limiting step in the absorption process (Perrut, Jung, and Leboeuf 2005;Van Nijlen et al. 2003). Supercritical antisolvent (SAS) processes have been widely used to precipitate active pharmaceutical ingredients (APIs) (Chattopadhyay and Gupta 2001;Rehman et al. 2001) with a high level of purity, suitable dimensional characteristics, narrow PSD, and spherical morphologies. The SAS process is based on the particular properties of the supercritical fluids (SCFs). These fluids have diffusivities two orders of magnitude larger than those of liquids, resulting in a faster mass transfer rate SCF properties (solvent power and selectivity) can be also adjusted continuously by altering the experimental conditions (temperature and pressure). As a consequence, SCFs can be removed from the process by a simple change from the supercritical to room conditions, which avoids difficult post-treatments of waste liquid streams. Carbon dioxide (CO 2 ) at supercritical conditions, among all possible SCFs, is largely used because of its relatively low critical temperature (31 1 C) and pressure (73.8 bar), low toxicity, and low cost. In this article, we show some results about processed antibiotics (ampicillin and amoxicillin), two of the world's most widely prescribed antibiotics, when they are dissolved in 1-methyl-2-pyrrolidone (NMP) and carbon dioxide is used as antisolvent.

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Screening design of experiment applied to supercritical antisolvent precipitation of amoxicillin

Cited by 16 publications

References 21 publications

Particles Formation Using Supercritical Fluids

Particles Formation Using Supercritical Fluids

Hydrodynamics Influence on Particles Formation Using SAS Process

Supercritical Antisolvent Process Applied to the Pharmaceutical Industry

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