Particles Formation Using Supercritical Fluids

Montes, A.; Gordillo, María Dolores Gordillo; Pereyra, C.; Ossa, E.J. Martı́nez de la

doi:10.5772/21271

Cited by 14 publications

(14 citation statements)

References 80 publications

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“…183 The top-down method starts from large crystals to small NCs in a step-by-step manner during a high-energy process, such as pearl milling and high-pressure homogenization. 182,[184][185][186] The bottom-up method involves procedures that start from molecules to NCs, such as solvent exchange, 21,[187][188][189] high-gravity-control precipitation, 188,190,191 evaporative precipitation, 192 rapid expansion of supercritical solution, 193 and supercritical antisolvent methods. 194 DNCs prepared via bottom-up methods need less energy and are smaller compared with those prepared through top-down methods.…”

Section: Drug Nanocrystalsmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

371

246

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Drug Nanocrystalsmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

371

246

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“…The very fast release of the solute in the gaseous medium should assure the production of very small particles. This process is particularly attractive due to the absence of organic solvents [9][10][11]. An interesting variation of the RESS process is the rapid expansion of a supercritical solution into a liquid solvent (RESOLV) that consists of spraying the supercritical solution into a liquid.…”

Section: Fig1 Ress Process Diagram [11]mentioning

confidence: 99%

“…The formation of the liquid mixture is very fast due to the enhanced mass transfer rates that characterize supercritical fluids and, as a result, nanoparticles could be produced (Fig. 2) [11,[36][37][38][39][40][41][42][43][44].…”

Section: Sasmentioning

confidence: 99%

“…The origin of GAS process is based on the fact that when a solution is expanded sufficiently by a gas, the liquid phase is no longer a good solvent for the solute and nucleation occurs. For example, a gaseous anti-solvent was used to reduce the lower critical solution temperature of polymer solutions to concentrate polymers [9,11]. Snavely et al [9] produced insulin (antidiabetic) nanoparticles by SAS with the aid of an ultrasonic nozzle.…”

Section: Fig2 Sas Process Diagram [11]mentioning

confidence: 99%

“…Such knowledge is essential to the utilization and optimization of supercritical fluid technology in materials preparation and processing [9][10][11]. Among the most important properties of a supercritical fluid are the low and tunable densities that can be varied between those of a gas and a normal liquid and the local density effects observed in supercritical fluid solutions (most strongly associated with near-critical conditions).…”

Section: Introductionmentioning

confidence: 99%

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Supercritical fluid (SCF) technology has become an important tool of materials processing in the last two decades. Supercritical CO 2 and H 2 O are extensively being used in the preparation of a great variety of nanomaterials. The interest in the preparation and application of nanometer size materials is increasing since they can exhibit properties of great industrial interest. Several techniques have been proposed to produce nanomaterials using supercritical fluids. These processes, taking advantage of the specific properties of supercritical fluids, are generally flexible, more simplified and with a reduced enviromental impact. The result is that nanomaterials with potentially better performances have been obtained. We propose a critical review of the supercritical based techniques applied to the production of nanoparticles materials.

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Polymeric nanoparticles (NPs) are one of the most studied organic strategies for nanomedicine. Intense interest lies in the potential of polymeric NPs to revolutionize modern medicine. To determine the ideal nanosystem for more effective and distinctly targeted delivery of therapeutic applications, particle size, morphology, material choice, and processing techniques are all research areas of interest. Utilizations of polymeric NPs include drug delivery techniques such as conjugation and entrapment of drugs, prodrugs, stimuli-responsive systems, imaging modalities, and theranostics. Cancer, neurodegenerative disorders, and cardiovascular diseases are fields impacted by NP technologies that push scientific boundaries to the leading edge of transformative advances for nanomedicine.

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Particles Formation Using Supercritical Fluids

Cited by 14 publications

References 80 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Nanotechnology and supercritical fluids

Polymeric nanoparticles: the future of nanomedicine

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