Hydrodynamics Influence on Particles Formation Using SAS Process

Montes, A.; Tenorio, A.; Gordillo, María Dolores Gordillo; Pereyra, C.; Ossa, E.J. Martı́nez de la

doi:10.5772/27809

Cited by 1 publication

(1 citation statement)

References 59 publications

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“…A similar positive effect of concentration on particle size and particle size distribution has been reported by many researchers. 38,39 Therefore, this result indicated mass transfer between scCO 2 and solution superimposed on the supersaturation and that it was also the single most important process parameter affecting nanoparticle formation. Otherwise, the higher supersaturation induced by higher concentration will result in smaller particle size and particle size distribution.…”

Section: Effect Of Concentration Of Silk Fibroin Solutionmentioning

confidence: 80%

Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO₂

Zhao

Chen

et al. 2013

Ind. Eng. Chem. Res.

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A solution-enhanced dispersion by supercritical CO2 (SEDS) was employed to prepare silk fibroin (SF) nanoparticles. The results of 24 full factorial experiment indicated that SF nanoparticles with particle size (PS) from 52.5 to 102.3 nm and particle size distribution (PSD) from 0.32 to 0.66 can be fabricated successfully. Moreover, reducing precipitation pressure or increasing concentration of SF solution, flow rate of SF solution, or precipitation temperature can increase PS and PSD of SF nanoparticles. The nanoparticle formation mechanism was elucidated through the formation and growth of SF nuclei in the gaseous miscible phase evolved from initial droplets generated by liquid–liquid phase split. Mass transfer between supercritical CO2 and SF solution superimposed on supersaturation was the most important process parameter affecting nanoparticle formation. Furthermore, Fourier transform infrared spectroscopy and X-ray powder diffraction analysis revealed that SF nanoparticles exhibited predominant random coil and α-helix structure with minor β-sheet conformation.

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Section: Effect Of Concentration Of Silk Fibroin Solutionmentioning

confidence: 80%

Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO₂

Zhao

Chen

et al. 2013

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

show abstract

Hydrodynamics Influence on Particles Formation Using SAS Process

Cited by 1 publication

References 59 publications

Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO₂

Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO₂

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Hydrodynamics Influence on Particles Formation Using SAS Process

Cited by 1 publication

References 59 publications

Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2

Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2

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Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO₂

Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO₂