Screening children with NF1 for optic pathway glioma – No

Pilling, Rachel; Taylor, R.

doi:10.1038/eye.2010.94

Cited by 10 publications

(5 citation statements)

References 15 publications

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“…Fifteen percent occurrence in our series is in agreement with the range of 1.5-24% in other series of OPGs, 24,25 implying that OPG is no more common in OFNF than in NF1, with predominant manifestation outside the head and face. Similar to previous reports, 12,18,19 most of our patients with OPG presented with decreased VA and/or proptosis, and neuroimaging generally revealed thickening and/or tortuosity of the optic nerve or chiasm. Biopsy was not undertaken, as the diagnosis of OPG was made by neuroimaging.…”

Section: Discussionsupporting

confidence: 71%

“…16 Finally, high-resolution neuroimaging of the optic nerves and chiasm is the most reliable way to make the diagnosis of OPG. 18,19 Similarly to previous studies, 10 the most common surgical procedures performed in our series were related to ptosis and lid involvement. The primary indications for lid surgery in OFNF were functional, with the goal of uncovering an obscured visual axis to prevent amblyopia in visually immature children (Figures 1 and 3).…”

Section: Discussionmentioning

confidence: 60%

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Orbitofacial neurofibromatosis: clinical characteristics and treatment outcome

Chaudhry

Morales

Shamsi

et al. 2011

Eye

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 60%

Orbitofacial neurofibromatosis: clinical characteristics and treatment outcome

Chaudhry

Morales

Shamsi

et al. 2011

Eye

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“…An important clinical aspect of the orbital ONG is its relationship to NF 1 (Von-Recklinghausen's disease) [70]. Although estimates vary considerably, most series with good available clinical data have reported a 40 to 50% incidence of NF 1 in patients with orbital ONG [71,72]. In as many as 95%, of patients, the diagnosis is made on the basis of clinical manifestations.…”

Section: Discussionmentioning

confidence: 99%

Paediatric orbital tumours in Upper Egypt: A 3-year retrospective analysis at a university hospital.

Abdallah¹,

Abdellatif²,

Elhwary³

et al. 2018

clinical-ophthalmology

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Purpose: To evaluate the relative frequencies, clinical profile, and treatment outcomes of Pediatric orbital tumours in Upper Egypt. Materials and Methods: In a retrospective, non-comparative, case series study, the authors reviewed the medical records of all children evaluated at Sohag University Hospital, from September 2014 till August 2017, with the diagnosis of orbital tumours and tumour-like lesions. The final diagnosis in each case was established by a combination of history, ophthalmic examination findings, imaging studies, and histopathologic examination if biopsy was performed. Results: A total of 92 orbital lesions were included in this study, which were classified into the following major categories: Cystic (28 cases, 30.4%), vascular (13 cases, 14.1%), Lipomatous (10 cases, 10.9%), inflammatory (9 cases, 9.8%), neurogenic (7 cases, 7.6%), lymphoid/leukemic (6 cases, 6.5%), myogenic (5 cases, 5.4%), lacrimal gland (5 cases, 5.4%), secondary (4 cases, 4.3%), metastatic (3 cases, 3.3%), and histiocytic (2 cases, 2.2%) orbital lesions in order of frequency. The clinical features and treatment outcomes of these lesions will be discussed. Conclusion: A variety of benign and malignant Pediatric orbital tumours may be seen in clinical practice. Management of these tumours requires a multidisciplinary approach. Early diagnosis and prompt treatment provide good cosmetic and functional results, and prevent visual loss in the majority of those children.

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“…Once an OPG has been detected, treatment decisions are not made on the basis of radiological change alone, since neuroimaging has not been shown to improve clinical outcomes, nor does early detection by MRI reduce the incidence of visual loss due to OPG 11. It is the ophthalmological examination that will determine whether there has been clinical deterioration and, therefore, whether treatment is warranted.…”

Section: Commentarymentioning

confidence: 99%