Paediatric orbital tumours in Upper Egypt: A 3-year retrospective analysis at a university hospital.

Abstract

Purpose: To evaluate the relative frequencies, clinical profile, and treatment outcomes of Pediatric orbital tumours in Upper Egypt. Materials and Methods: In a retrospective, non-comparative, case series study, the authors reviewed the medical records of all children evaluated at Sohag University Hospital, from September 2014 till August 2017, with the diagnosis of orbital tumours and tumour-like lesions. The final diagnosis in each case was established by a combination of history, ophthalmic examination findings, imaging studies, and histopathologic examination if biopsy was performed. Results: A total of 92 orbital lesions were included in this study, which were classified into the following major categories: Cystic (28 cases, 30.4%), vascular (13 cases, 14.1%), Lipomatous (10 cases, 10.9%), inflammatory (9 cases, 9.8%), neurogenic (7 cases, 7.6%), lymphoid/leukemic (6 cases, 6.5%), myogenic (5 cases, 5.4%), lacrimal gland (5 cases, 5.4%), secondary (4 cases, 4.3%), metastatic (3 cases, 3.3%), and histiocytic (2 cases, 2.2%) orbital lesions in order of frequency. The clinical features and treatment outcomes of these lesions will be discussed. Conclusion: A variety of benign and malignant Pediatric orbital tumours may be seen in clinical practice. Management of these tumours requires a multidisciplinary approach. Early diagnosis and prompt treatment provide good cosmetic and functional results, and prevent visual loss in the majority of those children.

Experience with Orbital Tumors from a Tertiary Cancer Centre of North East India: A Pathology Perspective

“…A review of the literature revealed marked differences between biopsy-proven studies, and clinically based studies. 2 Nonetheless, overall incidence of orbital tumors is 3.5 to 4%. 3 The major bias inherent in our study was the nature of the institute where the research was taken up.…”

“…So, histopathology is not always sufficient for an unequivocal diagnosis, necessitating ancillary studies. 2 IHC studies constitute the main approach to diagnosis. The markers typically found in RMS include antibodies against desmin (90%), myogenin (90%), myoD1 (71–91%), and myoglobin.…”