Question 1: Should a child with neurofibromatosis type 1 be screened for central nervous system tumours with neuroimaging?

Bodey, Caroline; Seal, Arnab

doi:10.1136/archdischild-2014-306047

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…We have studied a cohort of 64 children with NF1‐OPG and 7 had GHE: 10.9%. At our institution, according to international guidelines (Listernick, Louis, Packer, & Gutmann, ; Bodey & Seal, ; Blazo et al, ), brain MRI in children with NF1 is performed only in case of ophthalmologic or neurologic symptoms. Our study population was therefore composed of children with NF1 and symptomatic OPG, except for one boy, specifically submitted to MRI because of increased HV.…”

Section: Discussionmentioning

confidence: 99%

Growth hormone excess in children with neurofibromatosis type‐1 and optic glioma

Cambiaso

Galassi

Palmiero

et al. 2017

American J of Med Genetics Pt A

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In children with neurofibromatosis type 1 (NF1) and optic pathways glioma (OPG), growth hormone (GH) excess has been rarely reported and mainly associated to central precocious puberty. The aim of our study is to evaluate the prevalence of GH excess, the association with central precocious puberty, the relation with tumor site and the evolution over time in a large cohort of children with NF1 and OPG. Sixty-four NF1 children with OPG were evaluated. Patients with stature and/or height velocity >2 SD for age were studied for GH secretion. Seven out of 64 children (10.9%) with NF1 and optic pathways glioma showed GH excess, isolated in 5 cases and associated to central precocious puberty in 2. All the children with GH excess had a tumor involving the chiasma. Children with GH excess underwent medical treatment with lanreotide and a minimum clinical/biochemical follow up of 2 years is reported. The present study demonstrates that GH excess should be considered as a relative frequent endocrine manifestation in NF1 patients, similarly to central precocious puberty. Therefore, these patients should undergo frequent accurate auxologic evaluations. On the other hand, an increase in height velocity in children with NF1, even despite normal ophthalmological exams, can suggest the presence of OPG and therefore represents an indication to perform brain MRI.

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Section: Discussionmentioning

confidence: 99%

Growth hormone excess in children with neurofibromatosis type‐1 and optic glioma

Cambiaso

Galassi

Palmiero

et al. 2017

American J of Med Genetics Pt A

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“…Most tumors do not require treatment, although some may require shunting if hydrocephalus develops, or may warrant surgical resection or chemotherapy in the setting of clinical progression [6] . MRI screening in an asymptomatic child is not routinely performed, as early detection does not usually improve outcome, and radiographic findings have not been shown to predict clinical behavior [7] , [8] , [9] . Since neuroimaging is not obtained, little is known about presymptomatic radiographic characteristics of gliomas in children with NF1.…”

Section: Introductionmentioning

confidence: 99%

De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging

Zafar

Hsiao

Botteron

et al. 2016

Radiology Case Reports

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Fifteen to 20% of children with neurofibromatosis type 1 develop low-grade glial neoplasms. However, since neuroimaging is not routinely obtained until a child is clinically symptomatic, little is known about presymptomatic radiographic characteristics of gliomas in this at-risk population. Herein, we describe a child with neurofibromatosis type 1 who initially had normal brain imaging before the development of multifocal gliomas. Comparison of these serial images demonstrated that brain tumors can arise de novo in children with this cancer predisposition syndrome, further underscoring the limited prognostic value of normal baseline magnetic resonance imaging.

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Question 1: Should a child with neurofibromatosis type 1 be screened for central nervous system tumours with neuroimaging?

Cited by 2 publications

References 11 publications

Growth hormone excess in children with neurofibromatosis type‐1 and optic glioma

Growth hormone excess in children with neurofibromatosis type‐1 and optic glioma

De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging

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